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眼睑巨大默克尔细胞癌:病例报告及文献复习。

Giant Merkel cell carcinoma of the eyelid: a case report and review of the literature.

机构信息

TianJin Medical University Eye Center, 300084 TianJin, PR China.

出版信息

World J Surg Oncol. 2011 May 24;9:58. doi: 10.1186/1477-7819-9-58.

DOI:10.1186/1477-7819-9-58
PMID:21609425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3118133/
Abstract

Merkel cell carcinoma (MCC) is a rare cutaneous tumor and cases located in the eyelid have been described, but still its rarity may lead to difficulty in diagnosis and delay in treatment. A 51-year-old female patient that presented with large lesions in the eyelid underwent surgery after the diagnosis of acute chalazion. Following respiratory distress secondary to pulmonary metastasis, the patient's condition deteriorated and was not fit for complete excision treatment. Histopathological investigation of the biopsies, taken from the tumor, revealed that it was undifferentiated small cell carcinoma. Our aim with this paper is to point out that more cases should be reported for more effective diagnosis, histopathological study, clinical investigation, treatment and prognosis of this specific neoplasm.

摘要

默克尔细胞癌(Merkel cell carcinoma,MCC)是一种罕见的皮肤肿瘤,已有眼睑部位的病例报道,但由于其罕见性,可能导致诊断困难和治疗延误。一位 51 岁的女性患者,因眼睑出现大的病变而就诊,在诊断为急性睑板腺炎后接受了手术。随后,患者因肺转移继发呼吸窘迫,病情恶化,无法进行完全切除治疗。对取自肿瘤的活检进行组织病理学检查显示为未分化小细胞癌。我们撰写本文的目的是指出,应该报告更多的病例,以便对这种特定肿瘤进行更有效的诊断、组织病理学研究、临床调查、治疗和预后评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1727/3118133/f05cfe1887cd/1477-7819-9-58-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1727/3118133/661413c472dc/1477-7819-9-58-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1727/3118133/f05cfe1887cd/1477-7819-9-58-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1727/3118133/661413c472dc/1477-7819-9-58-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1727/3118133/f05cfe1887cd/1477-7819-9-58-2.jpg

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Oncol Lett. 2024 Jan 23;27(3):119. doi: 10.3892/ol.2024.14252. eCollection 2024 Mar.
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Merkel Cell Carcinoma of the Left Eyelid with Metastasis to the Left Submandibular Lymph Nodes: A Case Report and Brief Review.左眼睑 Merkel 细胞癌伴左下颌下淋巴结转移:一例报告及简要综述
Case Rep Ophthalmol Med. 2022 Feb 24;2022:4712301. doi: 10.1155/2022/4712301. eCollection 2022.

本文引用的文献

1
Merkel cell carcinoma of the eyelid: a report of 2 cases.眼睑默克尔细胞癌:2例报告
Can J Ophthalmol. 2010 Feb;45(1):85-6. doi: 10.3129/i09-184.
2
Intraoperative imprint cytology for evaluation of sentinel lymph nodes from Merkel cell carcinoma.用于评估默克尔细胞癌前哨淋巴结的术中印片细胞学检查
Am Surg. 2009 Jul;75(7):615-9.
3
Clinical course and prognostic factors of Merkel cell carcinoma of the skin.皮肤默克尔细胞癌的临床病程及预后因素
Br J Dermatol. 2009 Jul;161(1):90-4. doi: 10.1111/j.1365-2133.2009.09155.x. Epub 2009 Apr 29.
4
Merkel cell carcinoma co-existent with sebaceous carcinoma of the eyelid.Merkel细胞癌与眼睑皮脂腺癌并存。
J Cutan Pathol. 2009 Sep;36(9):983-6. doi: 10.1111/j.1600-0560.2008.01160.x. Epub 2008 Nov 9.
5
An unusual presentation of merkel cell carcinoma of the eyelid.眼睑默克尔细胞癌的一种不寻常表现。
Orbit. 2008;27(4):331-3. doi: 10.1080/01676830802224916.
6
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features.195例默克尔细胞癌确诊时的临床特征:AEIOU特征
J Am Acad Dermatol. 2008 Mar;58(3):375-81. doi: 10.1016/j.jaad.2007.11.020.
7
Clonal integration of a polyomavirus in human Merkel cell carcinoma.多瘤病毒在人类默克尔细胞癌中的克隆整合
Science. 2008 Feb 22;319(5866):1096-100. doi: 10.1126/science.1152586. Epub 2008 Jan 17.
8
Merkel cell carcinoma of the eyelid review of the literature and report of patients with Merkel cell carcinoma showing spontaneous regression.眼睑默克尔细胞癌:文献综述及默克尔细胞癌患者自发消退报告
Ophthalmology. 2008 Jan;115(1):195-201. doi: 10.1016/j.ophtha.2007.02.024. Epub 2007 May 25.
9
Merkel cell carcinoma masquerading as a chalazion.伪装成睑板腺囊肿的默克尔细胞癌。
Can J Ophthalmol. 2007 Jun;42(3):469-70.
10
Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy.默克尔细胞癌辅助治疗:当前数据支持放疗而非化疗。
J Am Acad Dermatol. 2007 Jul;57(1):166-9. doi: 10.1016/j.jaad.2007.03.011. Epub 2007 May 7.