Choi N W, Shettigara P T, Abu-Zeid H A, Nelson N A
Int J Cancer. 1977 Feb 15;19(2):167-71. doi: 10.1002/ijc.2910190205.
In a cohort of 23,146 pregnant females followed for 37-56 months subsequent to collection of prenatal sera, 57 cases of carcinoma of the cervix were encountered. Three controls were selected for each case from the residual cohort matched to cases for age, residence, number of prior cytology smears taken, and the data of entry to the study. The antibody activity to herpesvirus type 1 and type 2 was examined by the indirect hemagglutination test. The proportion of cases positive for HSV-2 infection was greater than that of the controls; however, the difference was not significant at the 5% level. The relative risk value for the association between HSV-2 infection and carcinoma of the cervix was found to be 2.33. The geometric mean titers of IHAT revealed that the cases of cervical cancer had a higher titer than the controls with respect to HSV-1 as well as HSV-2 antibodies. A sufficiently longer follow-up, yielding a larger sample size, is desired to assess the specific role of HSV-2 infection in development of cervical anaplasia.
在收集产前血清后对23146名怀孕女性进行了37至56个月随访的队列研究中，共发现57例宫颈癌病例。从剩余队列中为每例病例选取3名对照，对照在年龄、居住地、既往细胞学涂片检查次数以及进入研究的时间等方面与病例相匹配。采用间接血凝试验检测对1型和2型疱疹病毒的抗体活性。HSV - 2感染阳性病例的比例高于对照组；然而，在5%的水平上差异不显著。发现HSV - 2感染与宫颈癌之间关联的相对风险值为2.33。间接血凝试验的几何平均滴度显示，宫颈癌病例在HSV - 1以及HSV - 2抗体方面的滴度高于对照组。为了评估HSV - 2感染在宫颈间变发展中的具体作用，需要进行足够长时间的随访，以获得更大的样本量。
