Menczer J, Yaron-Schiffer O, Leventon-Kriss S, Modan M, Modan B
Cancer. 1981 Oct 1;48(7):1497-9. doi: 10.1002/1097-0142(19811001)48:7<1497::aid-cncr2820480702>3.0.co;2-i.
Sera from 16 Jewish patients with histologically confirmed adenocarcinoma of the uterine cervix (AUC) and 32 control subjects matched by age and ethnic origin were examined for herpesvirus type 1 (HSV-1) and type 2 (HSV-2) neutralizing antibodies. Titers were determined by means of the quantitative plaque reduction neutralization test on VERO cell monolayers, using HSV-1 strain VR3 and HSV-2 strain. Significantly increased levels of antibodies against both virus strains were found in the AUC patients as compared with the controls. The trends in the AUC series resembled those in a previous similar case-control study of squamous cell carcinoma of the uterine cervix (SUC). Thus, the previously observed association between HSV-2 and SUC is true for AUC as well, despite differences in the clinical and epidemiologic characteristics of the two malignancies.
对16名经组织学确诊为子宫颈腺癌（AUC）的犹太患者以及32名年龄和种族匹配的对照受试者的血清进行检测，以检测1型疱疹病毒（HSV-1）和2型疱疹病毒（HSV-2）中和抗体。使用HSV-1毒株VR3和HSV-2毒株，通过在VERO细胞单层上进行定量蚀斑减少中和试验来测定滴度。与对照组相比，在AUC患者中发现针对两种病毒毒株的抗体水平显著升高。AUC系列中的趋势与先前一项关于子宫颈鳞状细胞癌（SUC）的类似病例对照研究中的趋势相似。因此，尽管这两种恶性肿瘤在临床和流行病学特征上存在差异，但先前观察到的HSV-2与SUC之间的关联在AUC中同样成立。
