赞比亚CC趋化因子配体2的多态性与结核病相关。
Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia.
作者信息
Buijtels P C A M, van de Sande W W J, Parkinson S, Petit P L C, van der Sande M A B, van Soolingen D, Verbrugh H A, van Belkum A
机构信息
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
出版信息
Int J Tuberc Lung Dis. 2008 Dec;12(12):1485-8.
Polymorphism in various genes that may influence susceptibility to tuberculosis (TB) was examined in 46 TB patients and 119 healthy tuberculin-positive controls in Zambia. The odds of having TB was 2.8-fold higher in carriers of the -2518 AG single-nucleotide polymorphism in the promoter region of the CC-chemokine ligand 2 than in those carrying the homozygous genotype AA (95%CI 1.3-5.5).
在赞比亚，对46名结核病（TB）患者和119名结核菌素试验阳性的健康对照者进行了检测，以研究可能影响结核病易感性的各种基因的多态性。CC趋化因子配体2启动子区域-2518AG单核苷酸多态性的携带者患结核病的几率比携带纯合基因型AA的人高2.8倍（95%可信区间1.3 - 5.5）。
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