Beijing Pediatric Research Institute, Beijing Children's Hospital affiliated to Capital Medical University, Beijing, China.
Int J Tuberc Lung Dis. 2012 Feb;16(2):150-6. doi: 10.5588/ijtld.11.0205.
It has been found that the -2518 C-C motif ligand (CCL)-2 promoter variant increases the risk of developing active tuberculosis (TB).
To study the association between -2518 variants and susceptibility to TB.
We searched Medline, PubMed and the Wan Fang databases for human genetic studies on whether the -2518 CCL2 polymorphism influences the expression of active TB. Articles published from January 1998 to November 2010 were included. A random effects model was conducted in the meta-analysis.
The CCL2-2518G allele (OR 1.51, 95%CI 1.11-2.04, P = 0.008) showed significant association with susceptibility to TB. In genotype analysis, the recessive model (CCL2 genotype GG, OR 1.66, 95%CI 1.19-2.33, P = 0.003) was slightly superior to the dominant model (G carrier genotypes OR 1.53, 95%CI 1.07-2.17, P = 0.018). These observations were prominent among Asians and Latin-Americans of Hispanic ancestry, but not in Africans from Ghana and South Africa. The presence of epistatic genes in one population but not in the other, environmental differences and pathogen virulence may account for this.
The CCL2-2518G allele increases the risk of developing TB in Asians and Hispanics.
已经发现 -2518 C-C 基序配体 (CCL)-2 启动子变异增加了发展为活动性结核病 (TB) 的风险。
研究 -2518 变异与 TB 易感性之间的关系。
我们检索了 Medline、PubMed 和万方数据库，以寻找关于 -2518 CCL2 多态性是否影响活动性 TB 表达的人类遗传研究。纳入了 1998 年 1 月至 2010 年 11 月发表的文章。在荟萃分析中进行了随机效应模型。
CCL2-2518G 等位基因（OR 1.51，95%CI 1.11-2.04，P = 0.008）与 TB 易感性显著相关。在基因型分析中，隐性模型（CCL2 基因型 GG，OR 1.66，95%CI 1.19-2.33，P = 0.003）略优于显性模型（G 携带者基因型 OR 1.53，95%CI 1.07-2.17，P = 0.018）。这些观察结果在亚洲人和拉丁裔美洲人中尤为明显，但在加纳和南非的非洲人中则不明显。一个人群中存在上位基因而另一个人群中不存在，环境差异和病原体毒力可能是造成这种情况的原因。
CCL2-2518G 等位基因增加了亚洲人和西班牙裔人患 TB 的风险。
