Rozzini Luca, Vicini Chilovi Barbara, Bertoletti Erik, Conti Marta, Delrio Ilenia, Trabucchi Marco, Padovani Alessandro
Department of Neurology, Geriatric Research Group, University of Brescia, via Romanino 1, Brescia, Italy.
J Geriatr Psychiatry Neurol. 2008 Dec;21(4):261-7. doi: 10.1177/0891988708324940.
The aim of this study was to verify the usefulness of Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-Cog), in screening participants at risk of developing Alzheimer disease (AD) among populations with amnestic mild cognitive impairment(aMCI). 98 outpatients with aMCI were recruited. Participants were revaluated after 1 year: 44 (44.9%) were progressed to AD (progressors), while 54 (55.1%) did not convert (nonprogressors MCI). At baseline, cognitive performances were more impaired in progressors assessed by MMSE and by a neuropsychological battery. When tested with the ADAS-Cog subscale, the 2 groups of participants at baseline, progressors, and nonprogressors MCI, were significantly different regarding total score, memory, and nonmemory subitems. Considering a cutoff of 9.5 total score, adjusted for education, ADAS-Cog subscale showed a good performance (area under the curve = 0.67; sensitivity = 0.62%; specificity = 0.73%) in predicting conversion from aMCI to AD. Progressors aMCI were characterized at baseline by a greater cognitive impairment. ADAS-Cog subscale is a useful and brief cognitive assessment tool to screen aMCI participants converting to AD within 1 year.
本研究的目的是验证阿尔茨海默病评估量表认知子量表（ADAS-Cog）在筛查遗忘型轻度认知障碍（aMCI）人群中患阿尔茨海默病（AD）风险参与者方面的有效性。招募了98例aMCI门诊患者。1年后对参与者进行重新评估：44例（44.9%）进展为AD（进展者），而54例（55.1%）未转化（非进展者MCI）。在基线时，通过MMSE和神经心理测试电池评估，进展者的认知表现受损更严重。当用ADAS-Cog子量表进行测试时，两组基线参与者，即进展者和非进展者MCI，在总分、记忆和非记忆子项目方面存在显著差异。考虑到经教育调整后的总分临界值为9.5，ADAS-Cog子量表在预测从aMCI转化为AD方面表现良好（曲线下面积 = 0.67；敏感性 = 0.62%；特异性 = 0.73%）。进展性aMCI患者在基线时的特征是认知障碍更严重。ADAS-Cog子量表是一种有用且简短的认知评估工具，可用于筛查1年内转化为AD的aMCI参与者。
