Tsatali Marianna, Moraitou Despina, Gialaouzidis Moses, Bakoglidou Evaggelia, Psaltis Vasilis, Bertzes Natalia, Hassanin Hany Ibrahim, Emmanouilidou Eudokia, Totonidis Michael, Frantzi Nikoleta, Avdikou Konstantina, Gavra Andromachi, Diamantidou Alexandra, Kapsali Nikolina, Kouroundi Eleni, Tsolaki Magda
Greek Association of Alzheimer Disease and Related Disorders (GAADRD), Thessaloniki, Greece.
Department of Psychology, School of Humanities and Social Sciences, University of Western Macedonia, Kozani, Greece.
J Alzheimers Dis Rep. 2024 Mar 19;8(1):543-554. doi: 10.3233/ADR-230151. eCollection 2024.
Alzheimer's Disease Assessment Scale Cognitive Subscale (ADAS-Cog) is a widely used screening tool for detecting older adults with Alzheimer's disease among their cognitively healthy peers. A previous study in Greek population showed that ADAS-Cog-Greek (G) is a valid tool and can identify people with Alzheimer's disease from older adult control group; however, there is no current data about whether ADAS-Cog can differentiate older adults with mild cognitive impairment (MCI) from those who have subjective cognitive decline (SCD).
The current study aimed to examine the discriminant potential of ADAS-Cog-G in Greek older adults who meet the criteria for SCD or MCI.
Four hundred eighty-two community-dwelling older adults, visitors of the Greek Alzheimer Association and Related Disorders, were enrolled in the current study. One hundred seventy-six of them met the criteria for SCD and three hundred six had MCI.
Path analysis applied to the data showed that age, as well as educational level affected ADAS-Cog-G performance. Results showed that the cut-off scores, which better discriminate people with SCD from MCI as well as their sensitivity and specificity values, were extracted in participants with high educational level (13 educational years<) and mainly under the age of 75 years.
The current study provided evidence concerning the discriminant potential of ADAS-Cog-G to differentiate older adults with SCD from those with MCI in the Greek population, and therefore contributes to the relevant literature on the field.
阿尔茨海默病评估量表认知分量表（ADAS - Cog）是一种广泛用于在认知健康的同龄人中检测患有阿尔茨海默病的老年人的筛查工具。先前在希腊人群中的一项研究表明，希腊版ADAS - Cog（ADAS - Cog - G）是一种有效的工具，能够从老年对照组中识别出患有阿尔茨海默病的人；然而，目前尚无关于ADAS - Cog能否区分轻度认知障碍（MCI）老年人与主观认知下降（SCD）老年人的数据。
本研究旨在检验ADAS - Cog - G在符合SCD或MCI标准的希腊老年人中的判别潜力。
本研究纳入了482名居住在社区的老年人，他们均为希腊阿尔茨海默病协会及相关疾病组织的访客。其中176人符合SCD标准，306人患有MCI。
对数据进行的路径分析表明，年龄以及教育水平会影响ADAS - Cog - G的表现。结果显示，在教育水平较高（受教育年限<13年）且主要年龄在75岁以下的参与者中，提取出了能更好地区分SCD患者与MCI患者的临界分数及其敏感性和特异性值。
本研究提供了证据，证明ADAS - Cog - G在希腊人群中具有区分SCD老年人与MCI老年人的判别潜力，因此为该领域的相关文献做出了贡献。
