前沿：CD4+ T细胞衍生的白细胞介素-2对于依赖辅助的初始CD8+ T细胞反应至关重要。
Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.
作者信息
Wilson Elizabeth B, Livingstone Alexandra M
机构信息
Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences and University of Rochester Medical Center, Rochester, NY 14642, USA.
出版信息
J Immunol. 2008 Dec 1;181(11):7445-8. doi: 10.4049/jimmunol.181.11.7445.
CD4(+) T cell help is essential for primary CD8(+) T cell responses to noninflammatory Ags. IL-2 is one of the principal cytokines made by naive CD4(+) T cells, and we show in this study that it is an essential component of help. Adoptively transferred naive CD4(+) TCR-transgenic OT-II cells supported endogenous primary CD8(+) T cell responses, but IL-2-deficient OT-II cells were unable to provide help, although they responded to Ag in vivo and up-regulated CD40 ligand in vitro. Wild -type OT-II cells helped endogenous CD8(+) T cell responses in IL-2-deficient mice, but not in IL-2Ralpha-deficient mice. Thus, CD4(+) T cell-derived IL-2 is essential for CD8(+) T cell responses to noninflammatory, cell-associated Ags. We suggest that it is also a critical component of help for CD8(+) T cell responses to pathogens, because protective memory also requires CD8(+) T cell stimulation by IL-2 during priming.
CD4(+) T细胞辅助对于初始CD8(+) T细胞对非炎性抗原的应答至关重要。白细胞介素-2（IL-2）是初始CD4(+) T细胞产生的主要细胞因子之一，我们在本研究中表明它是辅助作用的重要组成部分。过继转移的初始CD4(+) TCR转基因OT-II细胞支持内源性初始CD8(+) T细胞应答，但IL-2缺陷的OT-II细胞无法提供辅助，尽管它们在体内对抗原作出反应并在体外上调了CD40配体。野生型OT-II细胞在IL-2缺陷小鼠中辅助内源性CD8(+) T细胞应答，但在IL-2Rα缺陷小鼠中则不然。因此，CD4(+) T细胞衍生的IL-2对于CD8(+) T细胞对非炎性、细胞相关抗原的应答至关重要。我们认为它也是CD8(+) T细胞对病原体应答的辅助作用的关键组成部分，因为保护性记忆在启动过程中也需要IL-2对CD8(+) T细胞的刺激。
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