Lin Jen-Wei, Chen Chun-Yu, Chen Wan-Ching, Chomel Bruno B, Chang Chao-Chin
Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung 402, Taiwan.
Graduate Institute of Veterinary Public Health, National Chung Hsing University, Taichung 402, Taiwan.
J Med Microbiol. 2008 Dec;57(Pt 12):1496-1501. doi: 10.1099/jmm.0.2008/004671-0.
An increasing number of Bartonella species originally isolated from small mammals have been identified as emerging human pathogens. During an investigation of Bartonella infection in rodent populations carried out in Taiwan in 2006, a total of 58 rodents were tested. It was determined that 10.3 % (6/58) of the animals were Bartonella bacteraemic. After PCR/RFLP analysis, four isolates were identified as Bartonella elizabethae and one isolate as Bartonella tribocorum. However, there was one specific isolate with an unrecognized PCR/RFLP pattern. After further sequence and phylogenetic analyses of the gltA, ftsZ and rpoB genes, and the 16S-23S rRNA intergenic spacer region, the results indicated that this specific isolate from Rattus norvegicus was closely related to human pathogenic 'Bartonella rochalimae'. Further studies need to be conducted to evaluate whether this rodent species could be a reservoir for 'B. rochalimae'.
越来越多最初从小型哺乳动物中分离出的巴尔通体物种被鉴定为新出现的人类病原体。2006年在台湾对啮齿动物群体进行巴尔通体感染调查期间，共检测了58只啮齿动物。确定10.3%（6/58）的动物存在巴尔通体菌血症。经过PCR/RFLP分析，4株分离株被鉴定为伊丽莎白巴尔通体，1株分离株被鉴定为三部落巴尔通体。然而，有一株特定的分离株具有无法识别的PCR/RFLP模式。对gltA、ftsZ和rpoB基因以及16S-23S rRNA基因间隔区进行进一步的序列和系统发育分析后，结果表明，这株来自褐家鼠的特定分离株与人类致病的“罗氏巴尔通体”密切相关。需要进行进一步研究以评估这种啮齿动物物种是否可能是“罗氏巴尔通体”的宿主。
