Tollefson Travis T, Senders Craig W, Sykes Jonathan M
Department of Otolaryngology-Head and Neck Surgery, University of California, Davis Medical Center, 2521 Stockton Blvd, Ste 7200, Sacramento, CA 95817, USA.
Arch Facial Plast Surg. 2008 Nov-Dec;10(6):395-400. doi: 10.1001/archfaci.10.6.395.
Cleft lip and palate deformities are the most common congenital abnormalities of the head and neck. Advancements in the various multidisciplinary fields involved in cleft management have substantially improved functional and aesthetic outcomes. The legitimacy of such controversial topics as gingivoperiosteoplasty, primary rhinoplasty, and presurgical nasoalveolar molding is heavily contested. Bone morphogenetic protein and other recombinant growth factors may play important roles in future cleft care. As the candidate alleles that contribute to cleft lip and palate are further elucidated, the complex interplay of environmental influence and genetic predisposition is emphasized. Translational research from fields such as fetal wound healing, tissue engineering, and gene therapy may have clinical applications as cleft care continues to evolve.
唇腭裂畸形是头颈部最常见的先天性异常。参与唇腭裂治疗的各个多学科领域的进展已显著改善了功能和美学效果。诸如牙龈骨膜成形术、一期鼻整形术和术前鼻牙槽塑形等有争议话题的合理性受到了激烈争论。骨形态发生蛋白和其他重组生长因子可能在未来的唇腭裂治疗中发挥重要作用。随着导致唇腭裂的候选等位基因被进一步阐明，环境影响和遗传易感性之间复杂的相互作用得到了强调。随着唇腭裂治疗的不断发展，来自胎儿伤口愈合、组织工程和基因治疗等领域的转化研究可能会有临床应用。
