脐带血干细胞治疗获得性免疫缺陷综合征。
Cord blood stem cell therapy for acquired immune deficiency syndrome.
机构信息
Department of Genetics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Stem Cells Dev. 2009 Jan-Feb;18(1):1-2. doi: 10.1089/scd.2008.0304.
Abstract
Cord blood stem cell transplantation is routinely used to treat hematopoietic diseases. Individuals who are homozygous for the 32 polymorphism of the CCR5 locus, encoding a co-receptor for HIV-1, are normal and are resistant to HIV infection. Here we suggest that public cord blood repositories are likely to contain CCR5 homozygous units that could be used as a therapy for HIV-infected individuals.
摘要
脐带血干细胞移植通常用于治疗血液疾病。编码 HIV-1 共受体的 CCR5 基因座的 32 位核苷酸多态性纯合子个体是正常的，并且对 HIV 感染具有抗性。在这里，我们建议公共脐带血库可能含有 CCR5 纯合子单位，可用于治疗 HIV 感染个体。
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