Sarrias Lorenz X, Bardón Otero E, Vila Paz M L
Hospital de Bellvitge, Barcelona.
Nefrologia. 2008;28 Suppl 3:119-22.
Predialysis is a clinical situation in which the patient has significant impairment of kidney function that will ultimately lead to either death or inclusion in kidney replacement therapy (dialysis and/or transplantation). Since a practical and effective dialysis technique was introduced, the length and quality of survival of patients with end-stage renal failure has constantly increased. Contraindications for dialysis are almost never of a renal origin. The obstacles are the concomitant diseases of the patient. The age of the patient may be one of these obstacles. The average age at initiation of dialysis in our country is currently 67 years and over 50% of patients are 60 years old or older. Decision making: From an ethical viewpoint, there is a consensus in stating that anything that can technically be done, should be done. The principle of nonmaleficence and respect for the autonomy of the patients are "prima facie" principles when the physician has doubts as to whether dialysis provides a benefit to the patient. The principle of autonomy, which makes the patient a competent subject of treatment, allows a framework of shared decisions to be created in which the physician uses his knowledge and experiences in assessing the risk and benefits of dialysis including the alternative of no dialysis. The competent patient, duly informed, will chose the option that is best for him and take the decision. Principle of treatment proportionality: This principle states that there is a moral obligation to implement all therapeutic measures that show a relationship of due proportion between the resources used and the expected result. Dialysis is in principle a proportional treatment for end-stage renal failure. However, it may become a disproportional treatment because of the physical and mental conditions of the elderly patient. The good that is sought with institution of treatment can cause a harm to the patient that justifies noninclusion of the patient in dialysis treatment. Because of the impossibility of establishing universal rules of proportionality, it is necessary to make a personal judgment of conscience in each specific case. Recommendations for initiation or not of dialysis: Taking shared decisions between the patient (or relatives and/or advisors) and the physician. These shared decisions will be documented with signing of the proposed informed consent or rejection of the treatment. The medical team should always be sure that the patients has fully understood the consequences of the decision taken. Explanation of the modalities should include: - Types of dialysis treatment available. - Not to initiate dialysis and continue with conservative treatment until death. This situation may cause many problems if we do not have the help of the palliative care service. - Try dialysis for a limited time. - Stop dialysis and receive medical care until death. - Evaluate the prognosis of renal disease and concomitant diseases, life expectancy and family support. Resolution of conflicts: Conflicts may occur: - Between nephrologist and patient/family. - Between members of the nephrological team. - Between nephrologist and other physicians. When conflicts persist and the need for initiation of dialysis is urgent, it is necessary to initiate treatment and continue it until the resolution of these conflicts, making a record of this decision. In such cases, the Hospital Ethics Care Committee can help with appropriate advice to solve the discrepancies. Decisions taken in advance may be useful in this type of patients. Patients with advanced chronic kidney disease with criteria for Noninclusion or withdrawal of dialysis. - Severe or irreversible dementia. - conditions of permanent unconsciousness. - advanced tumors with metastasis. - terminal disease of another nontransplantable organ. - severe physical and/or mental disabilities. (Strength of Recommendation C)
透析前是一种临床情况,即患者肾功能严重受损,最终将导致死亡或接受肾脏替代治疗(透析和/或移植)。自从引入实用且有效的透析技术以来,终末期肾衰竭患者的生存时长和质量持续提高。透析的禁忌证几乎都并非源于肾脏本身。障碍在于患者的伴随疾病。患者的年龄可能是其中一个障碍。我国目前开始透析的平均年龄为67岁,超过50%的患者年龄在60岁及以上。
从伦理角度来看,人们普遍认为,凡是技术上可行的事情都应该去做。当医生对透析是否能给患者带来益处存疑时,不伤害原则和尊重患者自主权是“首要”原则。自主权原则使患者成为有行为能力的治疗对象,从而能够建立一个共同决策的框架,在此框架中,医生运用自己的知识和经验来评估透析的风险和益处,包括不进行透析的选择。有行为能力且充分知情的患者会选择对自己最有利的选项并做出决定。
该原则指出,实施所有在所用资源与预期结果之间呈现适当比例关系的治疗措施存在道德义务。透析原则上是针对终末期肾衰竭的相称治疗方法。然而,由于老年患者的身体和精神状况,它可能会变成不相称的治疗。寻求通过治疗实现的益处可能会给患者造成伤害,这足以成为不将患者纳入透析治疗的理由。由于无法制定普遍适用的相称性规则,因此有必要在每个具体案例中进行个人的良心判断。
由患者(或亲属和/或顾问)与医生共同做出决策。这些共同决策将通过签署拟议的知情同意书或拒绝治疗来记录。医疗团队应始终确保患者充分理解所做决定的后果。对治疗方式的解释应包括:
可用的透析治疗类型。
不开始透析并继续进行保守治疗直至死亡。如果没有姑息治疗服务的帮助,这种情况可能会引发许多问题。
尝试进行有限时间的透析。
停止透析并接受医疗护理直至死亡。
评估肾病和伴随疾病的预后、预期寿命以及家庭支持情况。
可能会出现以下冲突:
肾病专家与患者/家属之间。
肾病团队成员之间。
肾病专家与其他医生之间。
当冲突持续存在且急需开始透析时,有必要开始治疗并持续进行,直至这些冲突得到解决,并记录这一决定。在这种情况下,医院伦理护理委员会可以提供适当建议以解决分歧。预先做出的决定在这类患者中可能会有所帮助。
严重或不可逆的痴呆。
永久性昏迷状态。
伴有转移的晚期肿瘤。
另一个不可移植器官的终末期疾病。
严重的身体和/或精神残疾。(推荐强度C)