Andrade Márcia Cristina Ribeiro, Leite José Paulo Gagliardi, Cabello Pedro Hernan
Department of Primatology, Center for Laboratory Animal Breeding, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
J Med Primatol. 2009 Feb;38(1):39-41. doi: 10.1111/j.1600-0684.2008.00301.x. Epub 2008 Nov 5.
Rhesus monkeys are relevant models for human diseases. The simian immunodeficiency virus (SIV) infection is an useful macaque model for assessing human immunodeficiency virus (HIV) vaccine strategies. Susceptibility and resistance to viruses have been associated with particular major histocompatibility complex (MHC) molecules. Several epitopes in the HIV structural and non-structural protein restricted by distinct MHC class I haplotypes are important targets for human cytotoxic T lymphocytes, which mediate protection against SIVmac infection. Mamu-A*01, for example, is a MHC class I molecule of rhesus monkeys that presents a peptide from SIV gag protein.
Our study determined the frequency of Mamu-A*01 in a closed colony of rhesus monkeys from Brazil by polymerase chain reaction.
A high frequency of the allele was found in the study colony.
This colony provides a significant source of A*01-positive animals to investigators.
恒河猴是人类疾病的相关模型。猿猴免疫缺陷病毒（SIV）感染是评估人类免疫缺陷病毒（HIV）疫苗策略的有用猕猴模型。对病毒的易感性和抗性与特定的主要组织相容性复合体（MHC）分子有关。受不同MHC I类单倍型限制的HIV结构和非结构蛋白中的几个表位是人类细胞毒性T淋巴细胞的重要靶点，这些细胞毒性T淋巴细胞介导对SIVmac感染的保护作用。例如，Mamu-A*01是恒河猴的一种MHC I类分子，它呈递来自SIV gag蛋白的一种肽。
我们的研究通过聚合酶链反应确定了来自巴西的一个封闭恒河猴群体中Mamu-A*01的频率。
在研究群体中发现该等位基因的频率很高。
这个群体为研究人员提供了大量A*01阳性动物的来源。
