长期链脲佐菌素诱导的糖尿病（STZ-DM）对食蟹猴（猕猴）的影响。
The effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on cynomolgus (Macaca fascicularis) monkeys.
作者信息
Wu D, Zou C, Yue F, Li X, Li S, Zhang Y A
机构信息
Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, Beijing, China.
出版信息
J Med Primatol. 2009 Feb;38(1):15-22. doi: 10.1111/j.1600-0684.2008.00300.x. Epub 2008 Nov 5.
BACKGROUND
This study aimed to retrospectively analyze the effect of long-term streptozotocin-induced diabetes mellitus (STZ-DM) on adolescent cynomolgus monkeys.
METHODS
A total of 12 monkeys (six STZ-DM and six controls) were monitored for fasting glucose levels and locomotor activities, tested for hematological and serum parameters, measured for body weight and somatometric values.
RESULTS
Fasting glucose was maintained at high levels in STZ-DM monkeys. At the age when normal adolescent monkeys dramatically increased their weight, STZ-DM led to the retardation of weight increase in diabetic monkeys. Moreover, STZ-DM monkeys showed abnormal lipid levels and somatometric measurements. In locomotor activity test, STZ-DM monkeys were more active than control ones.
CONCLUSIONS
Long-term STZ-DM disrupts the normal growth of young monkeys and interferes with some aspects of hormone, lipid metabolism and physical activities. Mean plasma glucose (MPG) appeared to be an important factor in physical activity abnormalities of STZ-DM monkeys.
背景
本研究旨在回顾性分析长期链脲佐菌素诱导的糖尿病（STZ-DM）对青春期食蟹猴的影响。
方法
总共12只猴子（6只STZ-DM猴子和6只对照猴子）被监测空腹血糖水平和运动活动，检测血液学和血清参数，测量体重和身体测量值。
结果
STZ-DM猴子的空腹血糖维持在高水平。在正常青春期猴子体重显著增加的年龄，STZ-DM导致糖尿病猴子体重增加迟缓。此外，STZ-DM猴子表现出异常的血脂水平和身体测量值。在运动活动测试中，STZ-DM猴子比对照猴子更活跃。
结论
长期STZ-DM会破坏幼猴的正常生长，并干扰激素、脂质代谢和身体活动的某些方面。平均血浆葡萄糖（MPG）似乎是STZ-DM猴子身体活动异常的一个重要因素。
Zotero 插件