超重中年食蟹猴的糖脂代谢变化
The changes of glucose and lipid metabolism in overweight middle-aged cynomolgus monkeys.
作者信息
Wu Di, Yue Feng, Zhang Yu A
机构信息
Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital University of Medical Science, and Key Laboratory of Neurodegeneration, Ministry of Education, Beijing, China.
出版信息
J Med Primatol. 2012 Dec;41(6):349-55. doi: 10.1111/j.1600-0684.2012.00556.x. Epub 2012 Aug 28.
BACKGROUND
Excessive weight gain has been observed in middle-aged cynomolgus monkeys. This study was designed to investigate the metabolic characteristics in overweight monkeys.
METHODS
A total of 26 cynomolgus monkeys were grouped based on gender and body weight. Overweight was operationally defined as body weight heavier than 9.6 kg in males and 7.5 kg in females. They were monitored for glucose and insulin in fasting state, serum parameters, and somatometric measurements.
RESULTS
Higher measurements of weight, body mass index (BMI), waist, hip, and waist/hip ratio (WHR) were the somatometric characteristics of overweight monkeys. Abdominal fat deposition was more prominent in females. Elevated total cholesterol, HDL-C, LDL-C, and fasting glucose were observed in female overweight monkeys. Impaired insulin sensitivity occurred in overweight monkeys.
CONCLUSIONS
Overweight could result in impaired insulin sensitivity. The metabolic changes were more prominent in female overweight monkeys.
背景
已观察到中年食蟹猴体重过度增加。本研究旨在调查超重猴的代谢特征。
方法
根据性别和体重将26只食蟹猴分组。超重的操作定义为雄性体重超过9.6千克，雌性体重超过7.5千克。对它们进行空腹状态下的血糖和胰岛素监测、血清参数检测以及身体测量。
结果
体重、体重指数（BMI）、腰围、臀围和腰臀比（WHR）测量值较高是超重猴的身体特征。腹部脂肪沉积在雌性中更为明显。在雌性超重猴中观察到总胆固醇、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和空腹血糖升高。超重猴出现胰岛素敏感性受损。
结论
超重可能导致胰岛素敏感性受损。代谢变化在雌性超重猴中更为突出。
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