Bentaleb A, Tagu P, Vascaut L
Service de pneumologie, Centre hospitalier général Jeanne-d'Arc, 1, boulevard d'Argonne, 55000 Bar-le-Duc, France.
Rev Pneumol Clin. 2008 Aug;64(4):178-82. doi: 10.1016/j.pneumo.2008.07.002. Epub 2008 Sep 18.
Unilateral acute pulmonary oedema (APO) is a rare radioclinical finding. It occurs secondary to multiple specific and rare pathological processes. Functional ischemic mitral regurgitation (FIMR) secondary to myocardial necrosis is one of the rare aetiologies involved in its pathogenesis. This concerns a 94-year-old male patient with a history of myocardial infarction who presented with a clinical picture of unilateral APO secondary to functional mitral regurgitation as a complication of myocardial necrosis. In addition to the clinical presentation and unilateral radiological findings, the diagnosis was based essentially on the electrocardiographic tracing, as well as changes in cardiac enzyme levels and transthoracic echocardiogram coupled with Doppler tissue imaging. This resulted after ruling out many differential diagnoses. Unilateral APO secondary to functional mitral regurgitation often presents diagnostic challenges and problems of initial management for the clinician. There are multiple aetiologies of acute unilateral pulmonary oedema, namely mechanical (re-expansion), lesional, vascular, bronchial obstructions, as well as iatrogenic causes, as is the case with some lung transplantations. As with all cases of APO, the treatment is based mainly on diuretics with high-flow oxygen therapy in association with an anticoagulant, which is usually effectively combined with a platelet aggregation inhibiting drug and sometimes with vasodilators and beta-blockers. Surgical treatment with valvuloplasty or valvular replacement appears to be the most effective means for preventing relapse.
单侧急性肺水肿(APO)是一种罕见的放射临床发现。它继发于多种特定且罕见的病理过程。心肌坏死继发的功能性缺血性二尖瓣反流(FIMR)是其发病机制中涉及的罕见病因之一。本文报道了一名94岁男性患者,有心肌梗死病史,因心肌坏死并发症功能性二尖瓣反流出现单侧APO的临床表现。除临床表现和单侧影像学表现外,诊断主要基于心电图、心肌酶水平变化、经胸超声心动图及多普勒组织成像。这是在排除许多鉴别诊断后得出的结果。功能性二尖瓣反流继发的单侧APO常常给临床医生带来诊断挑战和初始治疗难题。急性单侧肺水肿有多种病因,即机械性(复张性)、损伤性、血管性、支气管阻塞性,以及医源性原因,如某些肺移植情况。与所有APO病例一样,治疗主要基于利尿剂、高流量氧疗并联合抗凝剂,通常有效地联合血小板聚集抑制药物,有时联合血管扩张剂和β受体阻滞剂。瓣膜成形术或瓣膜置换术的手术治疗似乎是预防复发的最有效手段。