Lee Chieh-Hsun, Lai Ping-Hong, Liu Chin-San, Li Jie-Yuan
Division of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
J Neurol Sci. 2009 Feb 15;277(1-2):71-5. doi: 10.1016/j.jns.2008.10.011. Epub 2008 Nov 18.
The purpose of this study was to investigate the metabolic abnormalities in Kennedy disease (KD) patients using proton magnetic resonance spectroscopy. Five patients with KD showing typical phenotype were compared with eight age-matched, healthy control subjects. Relative metabolite concentrations for N-acetyl-aspartate (NAA), choline (Cho) and phosphocreatine (Cr) and lactate (Lac) were measured in the motor cortex and the brainstem area. In the motor cortex, NAA/Cr ratio was significantly reduced in KD patients (P=0.04). In the brainstem area, metabolic ratios including NAA/Cho, NAA/Cr and Cho/Cr failed to show significant difference between KD patients and normal controls. No pathologic Lac signal was noted in patients and controls. These findings corroborate a previous study indicating an involvement of the motor cortices in patients with KD.
本研究的目的是使用质子磁共振波谱研究肯尼迪病（KD）患者的代谢异常情况。将5例表现出典型表型的KD患者与8名年龄匹配的健康对照者进行比较。在运动皮层和脑干区域测量了N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、磷酸肌酸（Cr）和乳酸（Lac）的相对代谢物浓度。在运动皮层中，KD患者的NAA/Cr比值显著降低（P = 0.04）。在脑干区域，包括NAA/Cho、NAA/Cr和Cho/Cr在内的代谢比值在KD患者和正常对照之间未显示出显著差异。患者和对照中均未发现病理性Lac信号。这些发现证实了先前的一项研究，表明KD患者的运动皮层受累。
