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[化脓性肝脓肿:诊断与治疗]

[Pyogenic-liver abscess: diagnosis and management].

作者信息

Chiche L, Dargère S, Le Pennec V, Dufay C, Alkofer B

机构信息

Département de chirurgie viscérale et digestive, CHU de Caen, avenue de Côte-de-Nacre, 14000 Caen, France.

出版信息

Gastroenterol Clin Biol. 2008 Dec;32(12):1077-91. doi: 10.1016/j.gcb.2008.09.019. Epub 2008 Nov 18.

Abstract

Pyogenic-liver abscesses are due to bacteria mostly from the portal and biliary tracts. There is usually only one located in the right liver, but they may be found in the left liver, be multiple or multilocular. Diagnosis, based on ultrasound and/or computed tomography scan, is confirmed by percutaneous-needle aspiration to identify the bacteria causing the disease. Global management includes the treatment of sepsis and the aetiology of the liver abscess: biliary lithiasis, diverticular disease, colon cancer, appendicitis or other intra-abdominal infections. However, no cause is found in 20% of cases. Treatment is based on antibiotics and, sometimes, percutaneous drainage while the cause may be treated immediately or later if the sepsis is controlled. Interventional radiology is often used. Surgery may be performed in case of failure of initial treatment and to cure the cause of the abscess. Prognosis may be poor, especially if there are associated-risk factors, such as diabetes and immunodepression, even though the outcome has improved with a multidisciplinary approach.

摘要

化脓性肝脓肿主要由来自门静脉和胆道的细菌引起。通常只有一个位于右肝,但也可能出现在左肝,可为多个或多房性。基于超声和/或计算机断层扫描的诊断,通过经皮针吸来确定引起疾病的细菌得以确诊。整体治疗包括治疗脓毒症以及肝脓肿的病因:胆石症、憩室病、结肠癌、阑尾炎或其他腹腔内感染。然而,20%的病例未发现病因。治疗基于抗生素,有时还包括经皮引流,而病因可在脓毒症得到控制后立即或稍后进行治疗。常采用介入放射学方法。如果初始治疗失败或为了治愈脓肿病因,可能需要进行手术。预后可能较差,尤其是存在如糖尿病和免疫抑制等相关危险因素时,尽管多学科方法已使治疗结果有所改善。

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