深部脑刺激可能会改变异常的丘脑皮质动力学：利用脑磁图研究幻肢痛。

Abnormal thalamocortical dynamics may be altered by deep brain stimulation: using magnetoencephalography to study phantom limb pain.

作者信息

Ray N J, Jenkinson N, Kringelbach M L, Hansen P C, Pereira E A, Brittain J S, Holland P, Holliday I E, Owen S, Stein J, Aziz T

机构信息

University of Oxford, Department of Anatomy Physiology and Genetics, Parks Road, Oxford, OX1 3PT, UK.

出版信息

J Clin Neurosci. 2009 Jan;16(1):32-6. doi: 10.1016/j.jocn.2008.03.004. Epub 2008 Nov 18.

DOI:10.1016/j.jocn.2008.03.004

PMID:19019684

Abstract

Deep brain stimulation (DBS) is used to alleviate chronic pain. Using magnetoencephalography (MEG) to study the mechanisms of DBS for pain is difficult because of the artefact caused by the stimulator. We were able to record activity over the occipital lobe of a patient using DBS for phantom limb pain during presentation of a visual stimulus. This demonstrates that MEG can be used to study patients undergoing DBS provided control stimuli are used to check the reliability of the data. We then asked the patient to rate his pain during and off DBS. Correlations were found between these ratings and power in theta (6-9) and beta bands (12-30). Further, there was a tendency for frequencies under 25 Hz to correlate with each other after a period off stimulation compared with immediately after DBS. The results are interpreted as reflecting abnormal thalamocortical dynamics, previously implicated in painful syndromes.

摘要

深部脑刺激（DBS）用于缓解慢性疼痛。由于刺激器产生的伪迹，利用脑磁图（MEG）研究DBS治疗疼痛的机制存在困难。我们能够在视觉刺激呈现期间，对一名使用DBS治疗幻肢痛的患者的枕叶活动进行记录。这表明，只要使用对照刺激来检查数据的可靠性，MEG就可用于研究接受DBS治疗的患者。然后，我们让患者对DBS开启和关闭期间的疼痛进行评分。发现这些评分与θ波（6 - 9Hz）和β波（12 - 30Hz）的功率之间存在相关性。此外，与DBS刚结束时相比，在刺激停止一段时间后，低于25Hz的频率之间存在相互关联的趋势。这些结果被解释为反映了先前与疼痛综合征相关的异常丘脑皮质动力学。