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The combined use of hydroxyurea and anagrelide allows satisfactory hematologic control in patients with chronic myeloproliferative disorders and thrombocytosis: a report on 13 patients with poor tolerance to hydroxyurea monotherapy.

作者信息

D'adda Mariella, Micheletti Moira, Drera Monica, Ferrari Samantha, Rossi Giuseppe

出版信息

Leuk Lymphoma. 2008 Nov;49(11):2216-8. doi: 10.1080/10428190802353625.

DOI:10.1080/10428190802353625
PMID:19021067
Abstract
摘要

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1
The combined use of hydroxyurea and anagrelide allows satisfactory hematologic control in patients with chronic myeloproliferative disorders and thrombocytosis: a report on 13 patients with poor tolerance to hydroxyurea monotherapy.羟基脲与阿那格雷联合使用可使慢性骨髓增殖性疾病和血小板增多症患者获得满意的血液学控制：13例对羟基脲单药治疗耐受性差的患者报告
Leuk Lymphoma. 2008 Nov;49(11):2216-8. doi: 10.1080/10428190802353625.
2
Anagrelide is effective in treating patients with hydroxyurea-resistant thrombocytosis in patients with chronic myeloid leukemia.阿那格雷在治疗慢性粒细胞白血病中对羟基脲耐药的血小板增多症患者有效。
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3
[The use of anagrelide to treat thrombocytosis in connection with the chronic myeloproliferative disease].[使用阿那格雷治疗与慢性骨髓增殖性疾病相关的血小板增多症]
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New approaches to the treatment of thrombocytosis.血小板增多症的新治疗方法。
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Anagrelide: 20 years later.阿那格雷：20年后。
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Anagrelide: analysis of long-term efficacy, safety and leukemogenic potential in myeloproliferative disorders.阿那格雷：骨髓增殖性疾病的长期疗效、安全性及致白血病潜力分析
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Anagrelide, a therapy for thrombocythemic states: experience in 577 patients. Anagrelide Study Group.
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[Anagrelide--a new drug to reduce platelets in myeloproliferative diseases].
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Anagrelide-induced bone marrow changes during therapy of chronic myeloproliferative disorders with thrombocytosis. an immunohistochemical and morphometric study of sequential trephine biopsies.阿那格雷在治疗伴有血小板增多症的慢性骨髓增殖性疾病期间引起的骨髓变化。连续环钻活检的免疫组织化学和形态计量学研究。
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Anagrelide for thrombocytosis in myeloproliferative disorders: a prospective study to assess efficacy and adverse event profile.阿那格雷治疗骨髓增殖性疾病血小板增多症：一项评估疗效和不良事件特征的前瞻性研究。
Cancer. 2004 Nov 15;101(10):2239-46. doi: 10.1002/cncr.20646.

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Initial Low-Dose Hydroxyurea and Anagrelide Combination in Essential Thrombocythemia: Comparable Response with Lower Toxicity.原发性血小板增多症初始低剂量羟基脲与阿那格雷联合治疗：疗效相当且毒性更低
J Clin Med. 2024 May 14;13(10):2901. doi: 10.3390/jcm13102901.
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Essential Thrombocythemia in Adolescents and Young Adults: Clinical Aspects, Treatment Options and Unmet Medical Needs.
青少年和年轻成人特发性血小板增多症：临床特点、治疗选择和未满足的医学需求。
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Therapeutic options for patients with polycythemia vera and essential thrombocythemia refractory/resistant to hydroxyurea.真性红细胞增多症和原发性血小板增多症患者对羟基脲难治/耐药的治疗选择。
Leuk Lymphoma. 2014 Dec;55(12):2685-90. doi: 10.3109/10428194.2014.893310. Epub 2014 Mar 17.
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Combination therapy of hydroxycarbamide with anagrelide in patients with essential thrombocythemia in the evaluation of Xagrid(R) efficacy and long-term safety study.在评估Xagrid（R）疗效和长期安全性研究中，羟基脲与阿那格雷联合治疗原发性血小板增多症患者。
Haematologica. 2014 Apr;99(4):679-87. doi: 10.3324/haematol.2012.083097. Epub 2013 Dec 13.
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Thrombocytosis: diagnostic evaluation, thrombotic risk stratification, and risk-based management strategies.血小板增多症：诊断评估、血栓形成风险分层及基于风险的管理策略
Thrombosis. 2011;2011:536062. doi: 10.1155/2011/536062. Epub 2011 Jun 8.