Ravinsky Esther, Baker Patricia
Department of Pathology, Faculty of Medicine, University of Manitoba and Head, Section of Cytology, Department of Pathology, Health Sciences Centre, Winnipeg, Manitoba, Canada.
Diagn Cytopathol. 2009 Feb;37(2):81-5. doi: 10.1002/dc.20973.
We undertook this study to assess the characteristics of smears with features intermediate between high-grade squamous intraepithelial lesion (HSIL) and low-grade squamous intraepithelial lesion (ISIL). We also wanted to determine how these smears correlate with high risk biopsy diagnosis and to compare this with the biopsy correlation of LSIL and HSIL. Seventy-four squamous intraepithelial lesion (SIL) smears were identified as intermediate-grade SIL smears taken at colposcopy in a 1 year period. They were correlated with concurrent colposcopically guided biopsies. Thirty-five percent of cases with intermediate-grade SIL smears had a biopsy diagnosis of moderate dysplasia or higher as compared with 12% for LSIL 74% for HSIL. This confirmed our hypothesis that intermediate-grade SIL smears have a rate of biopsy diagnosis of moderate dysplasia or higher intermediate to that of LSIL and HSIL.
我们开展这项研究，以评估具有介于高级别鳞状上皮内病变（HSIL）和低级别鳞状上皮内病变（LSIL）之间特征的涂片的特点。我们还想确定这些涂片与高危活检诊断之间的关联，并将其与LSIL和HSIL的活检关联进行比较。在1年时间里，74例鳞状上皮内病变（SIL）涂片在阴道镜检查时被确定为中级SIL涂片。它们与同期阴道镜引导下的活检结果相关联。中级SIL涂片病例中有35%的活检诊断为中度发育异常或更高级别，相比之下，LSIL为12%，HSIL为74%。这证实了我们的假设，即中级SIL涂片的活检诊断为中度发育异常或更高级别的比例介于LSIL和HSIL之间。
