迈向内侧颞叶记忆系统的功能组织：海马旁回和内嗅皮质区域的作用
Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas.
作者信息
Eichenbaum Howard, Lipton Paul A
机构信息
Center for Memory and Brain, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA.
出版信息
Hippocampus. 2008;18(12):1314-24. doi: 10.1002/hipo.20500.
Abstract
Whereas substantial recent evidence has suggested to some that the medial entorhinal cortexá (MEC) plays a specialized role in spatial navigation, here we present evidence consistent with a broader role of the MEC in memory. A consideration of evidence on the anatomy and functional roles of medial temporal cortical areas and the hippocampus, and evidence from recordings from MEC neurons in rats performing a spatial memory task, suggest that the MEC may process information about both spatial and temporal context in support of episodic memory.
摘要
尽管最近有大量证据向一些人表明，内嗅皮质内侧（MEC）在空间导航中发挥着特殊作用，但在此我们提出的证据表明，MEC在记忆方面具有更广泛的作用。对内颞叶皮质区域和海马体的解剖结构及功能作用的证据进行考量，以及对执行空间记忆任务的大鼠MEC神经元记录所得的证据表明，MEC可能处理有关空间和时间背景的信息，以支持情景记忆。
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Hippocampus. 2008;18(12):1213-29. doi: 10.1002/hipo.20512.
2
Grid cells and theta as oscillatory interference: theory and predictions.网格细胞与作为振荡干扰的θ波：理论与预测
Hippocampus. 2008;18(12):1157-74. doi: 10.1002/hipo.20518.
3
A metric for space.一种空间度量。
Hippocampus. 2008;18(12):1142-56. doi: 10.1002/hipo.20483.
4
The hippocampus and memory: insights from spatial processing.海马体与记忆：来自空间处理的见解
Nat Rev Neurosci. 2008 Mar;9(3):182-94. doi: 10.1038/nrn2335.
5
Arc length coding by interference of theta frequency oscillations may underlie context-dependent hippocampal unit data and episodic memory function.θ频率振荡干扰下的弧长编码可能是情境依赖的海马体单元数据和情景记忆功能的基础。
Learn Mem. 2007 Nov 14;14(11):782-94. doi: 10.1101/lm.686607. Print 2007 Nov.
6
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7
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8
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