Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
Laboratory of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Japan.
Hippocampus. 2019 Dec;29(12):1238-1254. doi: 10.1002/hipo.23145. Epub 2019 Aug 13.
In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediating the encoding and storage of respectively what and where information hinges on the claim that a major component of their cortical connections is with the perirhinal cortex and postrhinal or parahippocampal cortex in, respectively, rodents or primates. In this scenario, the lateral entorhinal cortex and the perirhinal cortex are connectionally associated and likewise the postrhinal/parahippocampal cortex and the medial entorhinal cortex are partners. In contrast, here we argue that the connectivity matrix emphasizes the potential of substantial integration of cortical information through interactions between the two entorhinal subdivisions and between the perirhinal and postrhinal/parahippocampal cortices, but most importantly through a new observation that the postrhinal/parahippocampal cortex projects to both lateral and medial entorhinal cortex. We suggest that entorhinal inputs provide the hippocampus with high-order complex representations of the external environment, its stability, as well as apparent changes either as an inherent feature of a biological environment or as the result of navigating the environment. This thus indicates that the current connectional model of the parahippocampal region as part of the medial temporal lobe memory system needs to be revised.
在这篇综述中，我们旨在重新评估内嗅皮层的内在和外在网络组织，重点关注平行皮质连接流的概念。外侧和内侧内嗅皮层属于两个平行的输入-输出流的概念，分别介导“什么”和“哪里”信息的编码和存储，这一概念取决于一个主要的皮质连接成分是与同侧的边缘皮层和对侧的后边缘或副海马皮质的连接，分别在啮齿动物或灵长类动物中。在这种情况下，外侧内嗅皮层和边缘皮层在连接上是相关的，同样，后边缘/副海马皮层和内侧内嗅皮层也是伙伴。相比之下，我们在这里认为，连接矩阵强调了通过两个内嗅亚区之间以及边缘皮层和后边缘/副海马皮层之间的相互作用，对皮质信息进行实质性整合的潜力，但最重要的是通过一个新的观察结果，即后边缘/副海马皮层投射到外侧和内侧内嗅皮层。我们认为，内嗅皮层的输入为海马体提供了外部环境的高阶复杂表示，包括其稳定性以及明显的变化，这些变化既是生物环境的固有特征，也是在环境中导航的结果。因此，这表明需要对海马体作为内侧颞叶记忆系统一部分的当前连接模型进行修订。
