Ashida S, Hadley D W, Vaughn B K, Kuhn N R, Jenkins J F, Koehly L M
Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Clin Genet. 2009 Jan;75(1):43-9. doi: 10.1111/j.1399-0004.2008.01104.x. Epub 2008 Nov 17.
The associations between characteristics of family relationships and family trends in cancer worry and the psychological adjustment of recipients of genetic testing for cancer susceptibility were investigated. Data provided by 178 individuals from 24 families with Lynch syndrome who participated in a cohort study investigating psychological and behavioral outcomes of genetic testing were used. Responses from multiple family members were aggregated to construct family trends representing norms and departure from norms in cancer worry. Lower perceived family cohesion at baseline and decrease in this variable at 6 months after receipt of test results were associated with higher depression scores at 12 months. More variability in cancer worry among family members at baseline was also associated with higher depression scores at 12 months. Increase in family conflict was associated with decrease in depression scores among individuals from families with higher levels of cancer worry on average and less variability among the members. Family relationships and family trends in levels of cancer worry may play important roles in the psychological adjustment of genetic test recipients. The findings highlight the complexity of familial environment surrounding individuals that undergo genetic testing and suggest the benefits of considering these factors when providing genetic services.
研究了家庭关系特征与癌症担忧的家庭趋势以及癌症易感性基因检测受检者心理调适之间的关联。使用了来自24个患有林奇综合征家庭的178名个体提供的数据，这些个体参与了一项调查基因检测心理和行为结果的队列研究。汇总多个家庭成员的回答，以构建代表癌症担忧规范和偏离规范的家庭趋势。基线时较低的家庭凝聚力感知以及收到检测结果6个月后该变量的下降与12个月时较高的抑郁评分相关。基线时家庭成员间癌症担忧的更大变异性也与12个月时较高的抑郁评分相关。家庭冲突增加与平均癌症担忧水平较高且成员间变异性较小的家庭中个体的抑郁评分下降相关。家庭关系和癌症担忧水平的家庭趋势可能在基因检测受检者的心理调适中发挥重要作用。研究结果突出了接受基因检测个体周围家庭环境的复杂性，并表明在提供基因服务时考虑这些因素的益处。
