Neu Daniel, Hoffmann Guy, Moutrier Robert, Verbanck Paul, Linkowski Paul, Le Bon Olivier
University Hospital Brugmann, Sleep Laboratory, Université Libre de Bruxelles (ULB), Brussels, Belgium.
J Sleep Res. 2008 Dec;17(4):427-31. doi: 10.1111/j.1365-2869.2008.00679.x. Epub 2008 Oct 17.
It is presently unclear whether chronic fatigue syndrome (CFS) patients exhibit daytime sleepiness in addition to fatigue. Both, fatigue, such as that seen in CFS patients, and excessive daytime sleepiness, such as in sleep apnea-hypopnea syndrome (SAHS), remain poorly understood. Both daytime conditions are generally related to unrefreshing sleep and show affective symptoms. This study's objective was to contribute to the understanding of the relationship between fatigue and sleepiness in CFS patients not co-morbid for primary sleep or psychiatric disorders. We compared 16 untreated CFS patients (mean age 32.8, all females) with 13 untreated SAHS (mean age 47.7, all females) patients and 12 healthy controls (mean age 32.2, all females). Objective sleepiness was measured using multiple sleep latency tests (MSLT). Subjective sleepiness and fatigue were assessed with the Epworth Sleepiness Scale and the Fatigue Severity Scale, respectively. Mean Sleep Latency (SL) on the MSLT was significantly shorter in SAHS patients than in CFS patients and CFS patients showed significantly shorter mean SL than matched controls but within normal range. Subjective sleepiness was greatest in SAHS patients and subjective fatigue was highest in CFS patients. Affective symptoms showed highest intensities in CFS patients. While higher than the control group on all measures, compared to SAHS, the CFS group had higher subjective fatigue and lower subjective and objective sleepiness. Despite possible overlap in symptoms and signs of both daytime conditions, our data indirectly support the clinical distinction between fatigue and sleepiness.
目前尚不清楚慢性疲劳综合征（CFS）患者除疲劳外是否还表现出日间嗜睡。CFS患者出现的疲劳以及睡眠呼吸暂停低通气综合征（SAHS）患者出现的日间过度嗜睡，目前都还了解甚少。这两种日间状况通常都与睡眠未得到有效恢复有关，并且都伴有情感症状。本研究的目的是促进对未合并原发性睡眠或精神障碍的CFS患者疲劳与嗜睡之间关系的理解。我们将16名未经治疗的CFS患者（平均年龄32.8岁，均为女性）与13名未经治疗的SAHS患者（平均年龄47.7岁，均为女性）以及12名健康对照者（平均年龄32.2岁，均为女性）进行了比较。使用多次睡眠潜伏期试验（MSLT）来测量客观嗜睡程度。分别用Epworth嗜睡量表和疲劳严重程度量表评估主观嗜睡和疲劳情况。SAHS患者MSLT的平均睡眠潜伏期（SL）显著短于CFS患者，CFS患者的平均SL显著短于匹配的对照组，但仍在正常范围内。主观嗜睡在SAHS患者中最为严重，主观疲劳在CFS患者中最为严重。情感症状在CFS患者中强度最高。虽然在所有测量指标上CFS组均高于对照组，但与SAHS组相比，CFS组主观疲劳程度更高，主观和客观嗜睡程度更低。尽管这两种日间状况在症状和体征上可能存在重叠，但我们的数据间接支持了疲劳与嗜睡在临床上的区别。
