Maksoud Rebekah, Eaton-Fitch Natalie, Matula Michael, Cabanas Hélène, Staines Donald, Marshall-Gradisnik Sonya
National Centre for Neuroimmunology and Emerging Diseases (NCNED), Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia.
Consortium Health International for Myalgic Encephalomyelitis, Griffith University, Gold Coast 4222, Australia.
Healthcare (Basel). 2021 May 11;9(5):568. doi: 10.3390/healthcare9050568.
(1) Background-Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifaceted illness characterized by profound and persistent fatigue unrelieved by rest along with a range of other debilitating symptoms. Experiences of unrefreshing and disturbed sleep are frequently described by ME/CFS patients. This is the first systematic review assessing sleep characteristics in ME/CFS. The aim of this review is to determine whether there are clinical characteristics of sleep in ME/CFS patients compared to healthy controls using objective measures such as polysomnography and multiple sleep latency testing. (2) Methods-the following databases-Pubmed, Embase, Medline (EBSCO host) and Web of Science, were systematically searched for journal articles published between January 1994 to 19 February 2021. Articles that referred to polysomnography or multiple sleep latency testing and ME/CFS patients were selected, and further refined through use of specific inclusion and exclusion criteria. Quality and bias were measured using the Joanna Briggs Institute checklist. (3) Results-twenty observational studies were included in this review. The studies investigated objective measures of sleep quality in ME/CFS. Subjective measures including perceived sleep quality and other quality of life factors were also described. (4) Conclusions-Many of the parameters measured including slow- wave sleep, apnea- hypopnea index, spectral activity and multiple sleep latency testing were inconsistent across the studies. The available research on sleep quality in ME/CFS was also limited by recruitment decisions, confounding factors, small sample sizes and non-replicated findings. Future well-designed studies are required to understand sleep quality in ME/CFS patients.
（1）背景——肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种多方面的疾病，其特征是休息后无法缓解的深度和持续性疲劳以及一系列其他使人衰弱的症状。ME/CFS患者经常描述有睡眠不佳和睡眠障碍的经历。这是第一项评估ME/CFS睡眠特征的系统评价。本评价的目的是使用多导睡眠图和多次睡眠潜伏期测试等客观测量方法，确定ME/CFS患者与健康对照相比睡眠的临床特征。（2）方法——对以下数据库——PubMed、Embase、Medline（EBSCO主机）和Web of Science进行系统检索，以查找1994年1月至2021年2月19日发表的期刊文章。选择提及多导睡眠图或多次睡眠潜伏期测试以及ME/CFS患者的文章，并通过使用特定的纳入和排除标准进一步筛选。使用乔安娜·布里格斯研究所检查表测量质量和偏倚。（3）结果——本评价纳入了20项观察性研究。这些研究调查了ME/CFS患者睡眠质量的客观测量方法。还描述了包括感知睡眠质量和其他生活质量因素在内的主观测量方法。（4）结论——包括慢波睡眠、呼吸暂停低通气指数、频谱活动和多次睡眠潜伏期测试在内的许多测量参数在各项研究中并不一致。关于ME/CFS睡眠质量的现有研究还受到招募决策、混杂因素、样本量小和结果无法重复等限制。未来需要设计良好的研究来了解ME/CFS患者的睡眠质量。
