Huang H-T, Zon L I
Harvard Medical School, Stem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Cold Spring Harb Symp Quant Biol. 2008;73:111-8. doi: 10.1101/sqb.2008.73.029. Epub 2008 Nov 6.
Hematopoietic stem cells (HSCs) have been used extensively as a model for stem cell biology. Stem cells share the ability to self-renew and differentiate into multiple cell types, making them ideal candidates for tissue regeneration or replacement therapies. Current applications of stem cell technology are limited by our knowledge of the molecular mechanisms that control their proliferation and differentiation, and various model organisms have been used to fill these gaps. This chapter focuses on the contributions of the zebra fish model to our understanding of stem cell regulation within the hematopoietic system. Studies in zebra fish have been valuable for identifying new genetic and signaling factors that affect HSC formation and development with important implications for humans, and new advances in the zebra fish toolbox will allow other aspects of HSC behavior to be investigated as well, including migration, homing, and engraftment.
造血干细胞（HSCs）已被广泛用作干细胞生物学的模型。干细胞具有自我更新和分化为多种细胞类型的能力，使其成为组织再生或替代疗法的理想候选者。目前干细胞技术的应用受到我们对控制其增殖和分化的分子机制的了解的限制，并且已经使用各种模式生物来填补这些空白。本章重点介绍斑马鱼模型对我们理解造血系统内干细胞调节的贡献。斑马鱼研究对于识别影响人类造血干细胞形成和发育的新基因和信号因子具有重要价值，斑马鱼工具箱的新进展也将使造血干细胞行为的其他方面得以研究，包括迁移、归巢和植入。
