Abbate Francesco, Maugeri Alessandro, Laurà Rosaria, Levanti Maria, Navarra Michele, Cirmi Santa, Germanà Antonino
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Antioxidants (Basel). 2021 Apr 25;10(5):668. doi: 10.3390/antiox10050668.
The zebrafish is considered one of the most versatile experimental animal models. The transparency of the embryos, the small size, the rapid development and the homology with higher vertebrates have made the zebrafish a valuable model also for drug screening. Its use is closely related for the determination of bioactivity, toxicity and off-target side effects of novel drug candidates, which also allows a thorough evaluation of new targets; thus, it may represent a suitable model for drug screening and the optimization of novel candidates. Flavonoids are polyphenolic compounds widely present in fruits, vegetables and cereals. Polyphenols are important for both plants and humans, considering their involvement in defense mechanisms, particularly against oxidative stress. They protect plants from biotic and abiotic stressors and prevent or treat oxidative-based human diseases. For these reasons, polyphenols are used as nutraceuticals, functional foods and supplements by the pharmaceutical industry. Therefore, the most relevant findings on zebrafish as a useful experimental model to study oxidative stress-linked disorders, focusing on the biological activities of flavonoids, are here summarized and reviewed.
斑马鱼被认为是最通用的实验动物模型之一。胚胎的透明性、体型小、发育迅速以及与高等脊椎动物的同源性，使得斑马鱼成为药物筛选的宝贵模型。它的使用与新型候选药物的生物活性、毒性和脱靶副作用的测定密切相关，这也能够对新靶点进行全面评估；因此，它可能是药物筛选和新型候选药物优化的合适模型。黄酮类化合物是广泛存在于水果、蔬菜和谷物中的多酚类化合物。考虑到多酚参与防御机制，特别是对抗氧化应激，它们对植物和人类都很重要。它们保护植物免受生物和非生物应激源的影响，并预防或治疗基于氧化的人类疾病。出于这些原因，多酚被制药行业用作营养保健品、功能性食品和补充剂。因此，本文总结并综述了关于斑马鱼作为研究氧化应激相关疾病的有用实验模型的最相关研究结果，重点关注黄酮类化合物的生物活性。
