Accelerated utilization of lactate under the effect of hypoxen after intensive exercise.

作者信息

Grishina E V, Khaustova Ya V, Pogorelova V G, Pogorelov A G, Kuz'mich M K, Maevskii E I

机构信息

Laboratory of Biosystems Thermodynamics and Energy, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.

出版信息

Bull Exp Biol Med. 2008 Feb;145(2):198-201. doi: 10.1007/s10517-008-0049-y.

Administration of substrates of energy metabolism in combination with hypoxen (sulfur-containing oligoquinone) promoted the increase in blood lactate concentration during maximum exercise, accelerated lactate utilization, and reduced the lactate/pyruvate ratio during recovery. The in vivo effects are in line with hypoxen capacity to accelerate in vitro oxidation of exogenous NADH in mitochondria by the non-rotenone-dependent pathway realized with participation of cytochrome C.