Magakian Yu A, Karalova E M, Abroyan L O, Akopyan L A
Department of Physicochemical Biology of Cells, Institute of Molecular Biology, National Academy of Sciences of Republic of Armenia, Erevan.
Bull Exp Biol Med. 2008 Feb;145(2):202-6. doi: 10.1007/s10517-008-0050-5.
Similar behavior of lymphoid cells, their nuclei and nucleoli in periodic disease and leukemia attest to nonspecific reaction of the immune system to these diseases, but the intensity of this reaction and mechanisms of the population recovery are different. DNA hyperreplication plays an important role in this process: in periodic disease it is realized via gene amplification, which manifests by the formation of H2c nuclei and increase in the number of nucleoli, while in leukemia bone marrow lymphoblasts double the DNA content during S phase, maturate during G2 phase, and then divide. We called this mechanism "reserve lymphopoiesis" by analogy with reserve erythropoiesis discovered previously by us.
周期性疾病和白血病中淋巴细胞、其细胞核及核仁的类似行为证明了免疫系统对这些疾病的非特异性反应，但这种反应的强度及细胞群体恢复机制有所不同。DNA超复制在这一过程中起重要作用：在周期性疾病中，它通过基因扩增实现，表现为形成H2c细胞核及核仁数量增加，而在白血病中，骨髓淋巴母细胞在S期DNA含量翻倍，在G2期成熟，然后分裂。我们将此机制称为“储备淋巴细胞生成”，这是类比我们之前发现的储备红细胞生成而来。
