骨髓造血对紫杉醇毒性作用的反应。
Reaction of bone marrow hematopoiesis to the toxic effect of paclitaxel.
作者信息
Churin A A, Gol'dberg V E, Karpova G V, Voronova O L, Feodorova E P, Kolotova O V, Skurikhin E G, Pershina O V
机构信息
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2008 Feb;145(2):213-7. doi: 10.1007/s10517-008-0053-2.
Intraperitoneal injection of paclitaxel (Mitotax) in a single dose of 40 mg/kg was followed by an increase in the number of mitotic granulocytic and erythroid cells, hypoplasia, and pancytopenia of the bone marrow in CBA/CaLac mice. The test preparation decreased the number of hematopoietic precursor cells for erythropoiesis and granulocytopoiesis, but increased the count of polyploid cells and incidence of structural and genomic abnormalities in bone marrow cells. These changes were reversible.
对CBA/CaLac小鼠腹腔注射单剂量40mg/kg的紫杉醇（Mitotax）后，有丝分裂的粒细胞和红细胞数量增加，骨髓发育不全和全血细胞减少。受试制剂减少了红细胞生成和粒细胞生成的造血前体细胞数量，但增加了多倍体细胞数量以及骨髓细胞结构和基因组异常的发生率。这些变化是可逆的。
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