细胞间相互作用在细胞抑制诱导的骨髓抑制过程中对造血调控的作用。

Role of cell-cell interactions in the regulation of hemopoiesis during cytostatic-induced myelosuppression.

作者信息

Zhdanov V V, Udut E V, Gur'yantseva L A, Danilets M G, Dygai A M, Gol'dberg E D

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.

出版信息

Bull Exp Biol Med. 2001 Aug;132(2):744-7. doi: 10.1023/a:1013021726565.

DOI:10.1023/a:1013021726565

PMID:11713554

Abstract

The content of hemopoietic precursors in the bone marrow, its morphological composition, structural and functional organization, binding of hemopoietic precursors by adherent cells, and expression of receptors for erythroblasts and sialoadhesin on bone marrow macrophages were studied in CBA/CaLac mice with hypoplasia of hemopoiesis caused by etoposide in a maximum permissible dose. It was found that recovery of hemopoiesis after cytostatic treatment was related to accelerated maturation of hemopoietic precursors and increased ability of microenvironmental cells to bind hemopoietic cells.

摘要

在使用最大允许剂量依托泊苷导致造血功能低下的CBA/CaLac小鼠中，研究了骨髓中造血前体细胞的含量、其形态组成、结构和功能组织、黏附细胞对造血前体细胞的黏附以及骨髓巨噬细胞上成红细胞受体和唾液酸黏附素的表达。结果发现，细胞抑制治疗后造血功能的恢复与造血前体细胞的加速成熟以及微环境细胞黏附造血细胞的能力增强有关。