[急性食管坏死：一项回顾性病例系列研究]
[Acute esophageal necrosis: a retrospective case series].
作者信息
Ramos R, Mascarenhas J, Duarte P, Vicente C, Casteleiro C
机构信息
Servicio de Aparato Digestivo, Hospital Universitário de Covilhã, Quinta do Alvito, 6000-251 Covilhã, Portugal.
出版信息
Rev Esp Enferm Dig. 2008 Sep;100(9):583-5. doi: 10.4321/s1130-01082008000900010.
BACKGROUND
Acute esophageal necrosis has been considered a rare event. It is defined as the presence of diffuse dark pigmentation of the esophagus on upper endoscopy. Its incidence has not yet been established. The pathogenesis remains unknown.
PATIENTS AND METHODS
A retrospective analysis of clinical, laboratory, endoscopic, and histological data, and of the clinical course of 11 patients with acute necrotizing esophagitis was carried out over a 2-year period.
RESULTS
Among 3,976 patients who underwent upper endoscopy, 11 (0.28%) with acute esophageal necrosis were identified. Nutritional status was poor for 6 patients. Complete resolution of acute esophageal necrosis without further recurrence was observed in 4. One stricture appeared during follow-up and other patient developed new-onset acute esophageal necrosis. Seven patients died, but no death was directly related to acute esophageal necrosis.
CONCLUSIONS
The incidence of acute esophageal necrosis in our series is 0.28%. Acute esophageal necrosis is associated with high mortality rates.
背景
急性食管坏死一直被认为是一种罕见事件。它被定义为上消化道内镜检查时食管出现弥漫性深色色素沉着。其发病率尚未确定。发病机制仍不清楚。
患者与方法
对11例急性坏死性食管炎患者在2年期间的临床、实验室、内镜和组织学数据以及临床病程进行回顾性分析。
结果
在3976例行上消化道内镜检查的患者中，发现11例（0.28%）有急性食管坏死。6例患者营养状况较差。4例急性食管坏死完全缓解且无进一步复发。随访期间出现1例狭窄，另1例患者发生新发急性食管坏死。7例患者死亡，但无死亡与急性食管坏死直接相关。
结论
我们系列研究中急性食管坏死的发病率为0.28%。急性食管坏死与高死亡率相关。
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