Goldenberg S P, Wain S L, Marignani P
Department of Medicine, Griffin Hospital, Derby, Connecticut.
Gastroenterology. 1990 Feb;98(2):493-6. doi: 10.1016/0016-5085(90)90844-q.
Esophagitis of varying degrees and significance is caused by reflux, infections, radiation, and ingestion of chemical agents. A case of necrotizing esophagitis, seen as a black esophagus on endoscopy in a postoperative patient and resulting in long tubular stricture which ultimately required esophagectomy, is reported. Although the course of necrotizing esophagitis may parallel that associated with ischemia, severe caustic injury, or overwhelming infection, its etiology is uncertain. Diminished mucosal defenses, microbial implantation by a nasogastric tube placed perioperatively or sepsis, and transient ischemia with oxyradical formation and resultant reperfusion injury are hypothesized as important causative factors in the pathogenesis of acute necrotizing esophagitis.
不同程度和重要性的食管炎是由反流、感染、辐射以及化学制剂摄入引起的。本文报告了一例坏死性食管炎病例，该病例在内镜检查中表现为术后患者食管呈黑色，最终导致长管状狭窄，最终需要进行食管切除术。尽管坏死性食管炎的病程可能与缺血、严重腐蚀性损伤或严重感染相关的病程相似，但其病因尚不确定。黏膜防御功能减弱、围手术期放置鼻胃管导致的微生物植入或败血症，以及短暂性缺血伴氧自由基形成和由此产生的再灌注损伤被认为是急性坏死性食管炎发病机制中的重要致病因素。
