Kansagra Akash P, Menon Jayant P, Yarbrough Chester K, Urbaniak Klaudia, Waters J Dawn, Borys Ewa, Jandial Rahul
School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0606, USA.
J Neurosurg. 2009 Aug;111(2):301-5. doi: 10.3171/2008.9.JNS08718.
Balamuthia mandrillaris is a rare but increasingly recognized cause of amebic encephalitis, yet it remains poorly understood. The condition is almost universally fatal, and due to diagnostic difficulty, most cases are identified postmortem. The authors report a case of Balamuthia amebic encephalitis in a patient with combined variable immunodeficiency in which a rare antemortem diagnosis was made via brain biopsy. Despite broad-spectrum antimicrobial therapy, the outcome was fatal. Such presentations are challenging, and definitive diagnosis may require biopsy in consultation with a skilled neuropathologist.
曼氏巴通体是一种罕见但越来越被认可的阿米巴性脑炎病因，然而人们对其仍知之甚少。这种疾病几乎无一例外是致命的，而且由于诊断困难，大多数病例是在死后才得以确诊。作者报告了一例患有联合可变免疫缺陷的患者发生曼氏巴通体阿米巴性脑炎的病例，该病例通过脑活检在生前做出了罕见的诊断。尽管进行了广谱抗菌治疗，结果仍是致命的。此类病例具有挑战性，明确诊断可能需要在与经验丰富的神经病理学家会诊后进行活检。
