Gunn Alistair Jan, Bennet Laura
Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Clin Perinatol. 2008 Dec;35(4):735-48, vi-vii. doi: 10.1016/j.clp.2008.07.012.
There is strong evidence that prolonged, moderate cerebral hypothermia initiated within a few hours after severe hypoxia-ischemia and continued until resolution of the acute phase of delayed cell death can reduce neuronal loss and improve behavioral recovery in term infants and adults after cardiac arrest. This review examines the evidence that mild to moderate hypothermia is protective after hypoxia-ischemia in models of preterm brain injury and evaluates the potential risks. Induced hypothermia likely has potential to significantly reduce disability. Cautious, systematic trials are essential before hypothermia can be used in these vulnerable infants.
有强有力的证据表明，在严重缺氧缺血后数小时内开始并持续至迟发性细胞死亡急性期结束的长时间、适度的脑低温，可减少足月儿和心脏骤停后成人的神经元损失并改善行为恢复。本综述研究了在早产脑损伤模型中，轻至中度低温在缺氧缺血后具有保护作用的证据，并评估了潜在风险。诱导低温可能有显著降低残疾的潜力。在这些脆弱的婴儿中使用低温之前，谨慎、系统的试验至关重要。
