Menahan L A, Kemp R G
J Cyclic Nucleotide Res. 1976 Nov-Dec;2(6):417-25.
Changes in the cyclic AMP phosphodiesterase of the thymus were observed during leukemogenesis in the AKR mouse. Upon maturation, activity at 1.0 muM and 100 muM cyclic AMP concentrations decreased in both the AKR mouse and normal Swiss mice. The thymus of the leukemic mouse had sharply higher phosphodiesterase activity. Much of the phosphodiesterase activity of normal and leukemic mice was associated with particulate fractions, and, as indicated by marker enzymes for particulate components, the high affinity phosphodiesterase was enriched in a fraction containing plasma membranes.
在AKR小鼠白血病发生过程中观察到胸腺中环磷酸腺苷磷酸二酯酶的变化。成熟时，AKR小鼠和正常瑞士小鼠在1.0μM和100μM环磷酸腺苷浓度下的活性均降低。白血病小鼠的胸腺磷酸二酯酶活性明显更高。正常和白血病小鼠的大部分磷酸二酯酶活性与颗粒部分相关，并且，如颗粒成分的标记酶所示，高亲和力磷酸二酯酶在含有质膜的部分中富集。
