Krizanová O, Lacinová D, Knopp J
Acta Virol. 1977 Mar;21(2):97-103.
In chick embryo cells (CEC) and plasma membranes (PM) isolated therefrom, three forms of 3',5'-cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE) were demonstrated: (1) PDE activated only by Ca2+ (Ca-PDE); (2) PDE activated only by Mg2+ (Mg-PDE); and (3) PDE stimulated in the presence of 2 mM Mg2+ by low concentrations of Ca2+ (Ca-Mg-PDE). Purified influenza A virus, under suitable conditions, lowered the activities of these PDEs. The decrease was greater in samples incubated in the presence of adenosine triphosphate (ATP) than in those incubated in its absence.
在鸡胚细胞（CEC）及其分离出的质膜（PM）中，证实了三种形式的3',5'-环磷酸腺苷（cAMP）磷酸二酯酶（PDE）：（1）仅由Ca2+激活的PDE（Ca-PDE）；（2）仅由Mg2+激活的PDE（Mg-PDE）；以及（3）在2 mM Mg2+存在下被低浓度Ca2+刺激的PDE（Ca-Mg-PDE）。在合适的条件下，纯化的甲型流感病毒降低了这些PDE的活性。在存在三磷酸腺苷（ATP）的情况下孵育的样品中，这种降低比在不存在ATP的情况下孵育的样品中更大。
