Hamilton J A, Hart P H, Leizer T, Vitti G F, Campbell I K
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Australia.
J Rheumatol Suppl. 1991 Feb;27:106-9.
The plasminogen activator (PA)/plasmin system has been implicated in the inflammation and connective tissue remodelling occurring in arthritic joints. PA activity is detected in cultures of human monocytes, synoviocytes and chondrocytes and can be regulated by a variety of cytokines found in diseased joints; PA inhibitors (PAI-1 and/or PAI-2) are also produced by these cells. We have shown that human monocytes can synthesize both urokinase-type PA (u-PA) and tissue-type PA (t-PA). One cytokine present in rheumatoid synovial fluids, granulocyte macrophage colony stimulating factor (GM-CSF), stimulates monocyte u-PA production; since this cytokine can also be produced by activated monocytes and other cell types in joints, than a "CSF network" can be produced leading to u-PA production. Another monocyte cytokine, interleukin 1, causes human synoviocytes to increase their u-PA expression, a response which can be dependent on the presence of endogenous cyclooxygenase products; this cytokine also causes human chondrocytes and cartilage tissue to produce increased u-PA and t-PA activity, i.e., under conditions during which cartilage is resorbed.
纤溶酶原激活剂（PA）/纤溶酶系统与关节炎关节中发生的炎症和结缔组织重塑有关。在人单核细胞、滑膜细胞和软骨细胞培养物中可检测到PA活性，并且它可受到患病关节中多种细胞因子的调节；这些细胞也会产生PA抑制剂（PAI-1和/或PAI-2）。我们已经表明，人单核细胞能够合成尿激酶型PA（u-PA）和组织型PA（t-PA）。类风湿性滑液中存在的一种细胞因子，即粒细胞巨噬细胞集落刺激因子（GM-CSF），可刺激单核细胞产生u-PA；由于这种细胞因子也可由关节中活化的单核细胞和其他细胞类型产生，因此可能形成一个导致u-PA产生的“CSF网络”。另一种单核细胞细胞因子，白细胞介素1，可使人滑膜细胞增加其u-PA表达，这种反应可能依赖于内源性环氧化酶产物的存在；这种细胞因子还可使人软骨细胞和软骨组织产生增强的u-PA和t-PA活性，即在软骨被吸收的条件下。
