McNamara Bridgette J, Diouf Boucar, Hughson Michael D, Hoy Wendy E, Bertram John F
Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.
Nephrol Dial Transplant. 2009 May;24(5):1500-6. doi: 10.1093/ndt/gfn636. Epub 2008 Nov 21.
Glomerulomegaly has been associated with an increased risk of renal disease. Few reports have investigated the heterogeneity of glomerular size within kidneys and associated risk factors. This study measured the individual glomerular volume (IGV) of 720 non-sclerotic glomeruli in kidneys of adult West African males, and investigated associations of IGV with age, total glomerular (nephron) number and body surface area (BSA).
IGVs were determined in the kidneys of 24 Senegalese males from two age groups (12 subjects aged 20- 30 years and 12 subjects aged 50-70 years). Subjects were randomly chosen at autopsies performed at Le Dantec Hospital in Dakar. Volumes of 30 glomeruli per subject were determined using the disector/Cavalieri stereological method.
IGVs ranged from 1.31 x 10(6) microm3 to 12.40 x 10(6) microm3 (a 9.4-fold variation). IGV varied up to 5.3-fold within single kidneys. The trimmed range of IGV within subjects (10th to 90th percentile of IGV) was directly correlated with median glomerular size. The mean and standard deviation (SD) of IGV did not differ significantly between age groups or between subjects with higher (> or =1.78 m2) and lower BSA (<1.78 m2). In older subjects the SD of IGV was significantly and directly correlated with BSA. Kidneys with less than 1 million nephrons had significantly larger mean IGV than kidneys with more than 1 million nephrons, and the trimmed range of IGVs within subjects was inversely correlated with total glomerular number.
There was a considerable variation in IGV within kidneys of Senegalese males at autopsy. The heterogeneity of IGV was increased in association with low nephron number and increased BSA, with more pronounced effects in older subjects.
肾小球肿大与肾脏疾病风险增加相关。很少有报告研究肾脏内肾小球大小的异质性及相关危险因素。本研究测量了成年西非男性肾脏中720个非硬化性肾小球的个体肾小球体积（IGV），并研究了IGV与年龄、肾小球总数（肾单位）和体表面积（BSA）之间的关联。
对来自两个年龄组的24名塞内加尔男性（12名年龄在20 - 30岁，12名年龄在50 - 70岁）的肾脏进行IGV测定。在达喀尔勒丹泰克医院进行的尸检中随机选取受试者。使用分割器/卡瓦列里体视学方法确定每个受试者30个肾小球的体积。
IGV范围为1.31×10⁶立方微米至12.40×10⁶立方微米（相差9.4倍）。单个肾脏内IGV变化高达5.3倍。受试者体内IGV的修整范围（IGV的第10至90百分位数）与肾小球大小中位数直接相关。年龄组之间或体表面积较高（≥1.78平方米）和较低（<1.78平方米）的受试者之间，IGV的平均值和标准差无显著差异。在老年受试者中，IGV的标准差与体表面积显著且直接相关。肾单位少于100万个的肾脏的平均IGV显著大于肾单位多于100万个的肾脏，且受试者体内IGV的修整范围与肾小球总数呈负相关。
尸检时塞内加尔男性肾脏内IGV存在相当大的差异。IGV的异质性随着肾单位数量减少和体表面积增加而增加，在老年受试者中影响更为明显。
