Kwee I L, Nakada T, Suzuki N
Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, CA 94553.
NMR Biomed. 1991 Feb;4(1):38-40. doi: 10.1002/nbm.1940040107.
31P and 3-fluoro-3-deoxy-D-glucose (3-FDG) 19F nuclear magnetic resonance (NMR) spectroscopic investigations were performed on aged rat brain in vivo. Phosphodiester (PDE) was found to be significantly higher (p less than 0.05) in aged brain (18 months, n = 10) than adult controls (6 months, n = 10) suggesting accelerated phospholipid catabolism in aged brain. Inorganic phosphate (Pi) levels were significantly lower (p less than 0.05) in aged brain (n = 5) than in normal adult controls (n = 5). The sorbitol index, a measure of aldose reductase activities in vivo, determined by the 3-FDG 19F NMR method, revealed that aldose reductase activities were significantly higher (p less than 0.05) in aged brain.
对老年大鼠脑进行了体内31P和3-氟-3-脱氧-D-葡萄糖（3-FDG）19F核磁共振（NMR）光谱研究。发现老年脑（18个月，n = 10）中的磷酸二酯（PDE）显著高于成年对照组（6个月，n = 10）（p < 0.05），提示老年脑磷脂分解代谢加速。老年脑（n = 5）中的无机磷酸盐（Pi）水平显著低于正常成年对照组（n = 5）（p < 0.05）。通过3-FDG 19F NMR方法测定的山梨醇指数，即体内醛糖还原酶活性的指标，显示老年脑中醛糖还原酶活性显著更高（p < 0.05）。
