《实验药理学手册》“树突状细胞”：地塞米松在诱导耐受性树突状细胞中的应用

Handbook of experimental pharmacology "dendritic cells": the use of dexamethasone in the induction of tolerogenic DCs.

作者信息

van Kooten Cees, Stax Annelein S, Woltman Andrea M, Gelderman Kyra A

机构信息

Department of Nephrology, Leiden University Medical Center, C3P, Albinusdreef 2, P.O. Box 9600, Leiden, NL-2300RC, The Netherlands.

出版信息

Handb Exp Pharmacol. 2009(188):233-49. doi: 10.1007/978-3-540-71029-5_11.

DOI:10.1007/978-3-540-71029-5_11

PMID:19031029

Abstract

Dendritic cells (DCs) have a central role in immune regulation, ranging from tolerance induction to the induction of specific immune responses. DCs serve as an essential link between innate and adaptive immunity. This broad range of powerful immune stimulatory as well as regulatory functions has made DCs as targets for vaccine development strategies. One approach to promote the tolerogenicity of DCs is to suppress their maturation by pharmacological agents, including glucocorticoids (GCs). In the present chapter we will review GCs used in vitro with cultured DCs, applied in vivo, or used to generate tolerogenic DCs for cellular therapy.

摘要

树突状细胞（DCs）在免疫调节中起着核心作用，涵盖从诱导免疫耐受到诱导特异性免疫反应的各个方面。DCs是固有免疫和适应性免疫之间的重要连接。DCs具有广泛而强大的免疫刺激以及调节功能，这使其成为疫苗开发策略的靶点。促进DCs耐受性的一种方法是通过包括糖皮质激素（GCs）在内的药物抑制其成熟。在本章中，我们将综述在体外与培养的DCs一起使用、在体内应用或用于生成用于细胞治疗的耐受性DCs的糖皮质激素。