Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia, and Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Int Rev Immunol. 2010 Dec;29(6):574-607. doi: 10.3109/08830185.2010.522280.
Dendritic cells (DCs) constitute a unique set of antigen-presenting cells (APCs), equipped with the potential to initiate strong immune responses as well as to critically regulate immunity. Tolerogenic or "alternatively activated" DCs show remarkable properties in regulating immune responses both in vitro and in vivo. Furthermore, tolerogenic DCs are now beginning to be tested in clinical studies. Use of pharmacological agents to induce maturation-resistant tolerogenic DCs is a popular approach. In this review, we will discuss already recognized, as well as recently discovered, potential pharmacological agents, their mechanism of action, and the way in which they induce tolerance in DCs.
树突状细胞 (DCs) 构成了一组独特的抗原呈递细胞 (APCs)，具有引发强烈免疫反应以及严格调控免疫的潜力。耐受或“替代性激活”的 DCs 在体外和体内调节免疫反应方面表现出显著的特性。此外，耐受的 DCs 现在开始在临床研究中进行测试。使用药理制剂来诱导成熟抵抗性耐受的 DCs 是一种很受欢迎的方法。在这篇综述中，我们将讨论已经被认识到的，以及最近发现的潜在的药理制剂，它们的作用机制，以及它们诱导 DC 耐受的方式。
