白细胞介素-18基因多态性（-137C）与系统性红斑狼疮关节炎表现的关联：与干扰素γ基因多态性（+874A）的联合效应
Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A).
作者信息
Hirankarn Nattiya, Tangwattanachuleeporn Marut, Wongpiyabovorn Jongkonnee, Wongchinsri Jeerapat, Avihingsanon Yingyos
机构信息
Lupus Research Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Bangkok 10330, Thailand.
出版信息
Clin Rheumatol. 2009 Feb;28(2):219-23. doi: 10.1007/s10067-008-1036-4. Epub 2008 Nov 25.
We analyzed the association between single nucleotide polymorphisms in IL-12 and IL-18 genes in disease susceptibility and severity of SLE in Thais. A weak association was observed between A allele of the IL-12 gene at the 3' untranslated region in SLE patients with proteinuria (OR = 1.89, 95% CI = 1.05-3.40, P = 0.02, Pc = 0.06). In addition, we found a significant association between C allele of IL-18 (-137) with arthritis (OR = 6.88, 95% CI = 1.54-42.93, P = 0.003, Pc = 0.009). The presence of one C allele (C/C+C/G) was associated with significant OR of 8.72 (95% CI = 1.83-56.71, P = 0.001, Pc = 0.003). Interestingly, we found the combined effect between the G/C genotype of IL-18 (-137) and the A/A genotype of IFNG (+874) gene causing susceptibility of arthritis in SLE patients (OR = 13.22, 95% CI = 1.56-291.66, P = 0.004).
我们分析了泰国人白细胞介素-12（IL-12）和白细胞介素-18（IL-18）基因中的单核苷酸多态性与系统性红斑狼疮（SLE）疾病易感性及严重程度之间的关联。在有蛋白尿的SLE患者中，观察到IL-12基因3'非翻译区的A等位基因与疾病存在弱关联（比值比[OR]=1.89，95%置信区间[CI]=1.05 - 3.40，P = 0.02，校正P值[Pc]=0.06）。此外，我们发现IL-18（-137）的C等位基因与关节炎存在显著关联（OR = 6.88，95% CI = 1.54 - 42.93，P = 0.003，Pc = 0.009）。存在一个C等位基因（C/C + C/G）与显著的OR值8.72相关（95% CI = 1.83 - 56.71，P = 0.001，Pc = 0.003）。有趣的是，我们发现IL-18（-137）的G/C基因型与干扰素-γ（IFNG）（+874）基因的A/A基因型之间存在联合效应，导致SLE患者患关节炎的易感性增加（OR = 13.22，95% CI = 1.56 - 291.66，P = 0.004）。
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