Department of Epidemiology, School of Public Health, Fudan University, China.
BMC Med Genet. 2012 Nov 15;13:107. doi: 10.1186/1471-2350-13-107.
Interleukin (IL)-18, an important proinflammatory cytokine, plays a potential pathological role in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Studies on the relationship of IL-18 gene promoter rs1946518 (-607A/C) polymorphism, rs187238 (-137G/C) polymorphism with RA and SLE are inconclusive. The aim of this study was to get a more precise estimation of the relationship in Asian populations.
Meta-analysis was conducted on the associations between the IL-18 (-607A/C and -137G/C) polymorphisms and RA and SLE, using; (1) allele contrast, (2) dominant, and (3) recessive models. A total of 11 studies were included in this study.
For the relationship of IL-18 rs1946518 polymorphism with RA (additive model: OR=0.752, 95%CI=0.562-1.006; dominant model: OR=0.730, 95%CI =0.479-1.113; recessive model: OR=0.537, 95%CI=0.271-1.064) and SLE (additive model: OR=0.684, 95%CI=0.455-1.028; dominant model: OR=0.645, 95%CI=0.368-1.130; recessive model: OR=0.672, 95%CI =0.447-1.010), no significant association with RA and SLE risk can be found under all genetic models in Asian populations. However, significant associations were observed in Chinese population for both RA ((OR=0.688, 95%CI =0.532-0.889) and SLE (OR=0.606, 95%CI =0.396-0.930) under additive model. For the relationship between IL-18 rs187238 polymorphism and RA or SLE, there was no significant association detected in all genetic models, even in Chinese population.
This meta-analysis indicates that the IL-18-607A/C polymorphism may confer susceptibility to RA and SLE in Chinese population, but not all Asians.
白细胞介素 (IL)-18 是一种重要的促炎细胞因子，在类风湿关节炎 (RA) 和系统性红斑狼疮 (SLE) 中具有潜在的病理作用。关于 IL-18 基因启动子 rs1946518(-607A/C) 多态性、rs187238(-137G/C) 多态性与 RA 和 SLE 的关系的研究尚无定论。本研究旨在对亚洲人群的这种关系进行更精确的评估。
采用等位基因对照、显性和隐性模型对 IL-18(-607A/C 和-137G/C) 多态性与 RA 和 SLE 的关系进行荟萃分析。共纳入 11 项研究。
对于 IL-18 rs1946518 多态性与 RA（加性模型：OR=0.752，95%CI=0.562-1.006；显性模型：OR=0.730，95%CI=0.479-1.113；隐性模型：OR=0.537，95%CI=0.271-1.064）和 SLE（加性模型：OR=0.684，95%CI=0.455-1.028；显性模型：OR=0.645，95%CI=0.368-1.130；隐性模型：OR=0.672，95%CI=0.447-1.010）的关系，在亚洲人群中，所有遗传模型均未发现与 RA 和 SLE 风险显著相关。然而，在中国人群中，RA（OR=0.688，95%CI=0.532-0.889）和 SLE（OR=0.606，95%CI=0.396-0.930）的加性模型均存在显著关联。对于 IL-18 rs187238 多态性与 RA 或 SLE 的关系，在所有遗传模型中均未检测到显著关联，即使在中国人群中也是如此。
本荟萃分析表明，IL-18-607A/C 多态性可能在中国人群中导致 RA 和 SLE 的易感性，但并非所有亚洲人群都是如此。
