Kupfer D J
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pa 15213.
J Clin Psychiatry. 1991 May;52 Suppl:28-34.
Because recurrent depression represents a major public health problem, the successful long-term treatment of individuals who develop repeated episodes of depression has become a high clinical priority. Effective preventive treatment requires continued pharmacologic management for most individuals with recurrent depression. Although the efficacy of tricyclic antidepressants or lithium carbonate in preventive treatment has been well established, evidence is less clear for monomaine oxidase inhibitors and the newer antidepressants. In addition to the need for more long-term studies on the new compounds, the role of psychotherapy as combination treatment needs to be further elucidated.
由于复发性抑郁症是一个重大的公共卫生问题，成功地长期治疗出现反复抑郁发作的个体已成为临床的高度优先事项。对于大多数复发性抑郁症患者而言，有效的预防性治疗需要持续的药物管理。尽管三环类抗抑郁药或碳酸锂在预防性治疗中的疗效已得到充分证实，但单胺氧化酶抑制剂和新型抗抑郁药的证据尚不明确。除了需要对新化合物进行更多长期研究外，心理治疗作为联合治疗的作用也需要进一步阐明。
