Binétruy B, Smeal T, Karin M
Department of Pharmacology, School of Medicine, University of California San Diego, La Jolla 92093.
Nature. 1991 May 9;351(6322):122-7. doi: 10.1038/351122a0.
Ha-Ras augments c-Jun-mediated transactivation by potentiating the activity of the c-Jun activation domain. Ha-Ras also causes a corresponding increase in phosphorylation of specific sites in that part of the c-Jun protein. A Ha-Ras-induced protein kinase cascade resulting in hyperphosphorylation of the c-Jun activation domain could explain how these oncoproteins cooperate to transform rat embryo fibroblasts.
Ha-Ras通过增强c-Jun激活域的活性来增强c-Jun介导的反式激活作用。Ha-Ras还会使c-Jun蛋白该部分中特定位点的磷酸化相应增加。由Ha-Ras诱导的蛋白激酶级联反应导致c-Jun激活域的过度磷酸化，这可以解释这些癌蛋白如何协同作用转化大鼠胚胎成纤维细胞。
