Bodner-Adler Barbara, Lozano Plamen, Bodner Klaus, Zeisler Harald
Department of Obstetrics and Gynecology, University of Vienna Medical School, Vienna, Austria.
Anticancer Res. 2008 Sep-Oct;28(5B):3083-5.
Uterine leiomyosarcoma during pregnancy is an extremely rare event. The incidence of meningioma during pregnancy is comparable with that in nonpregnant women of the same age group. We report a case of both--a primary uterine leiomyosarcoma and additionally an atypical meningioma of the brain both diagnosed during pregnancy.
The patient was admitted with generalised seizures at 31 weeks of gestation. A tumoural mass was detected and initial conservative treatment was started. The patient delivered her infant via caesarean section, at 34 weeks of gestation. During caesarean section a pedunculated uterine fibroid was removed and total gross resection due to the brain tumour was also performed. Histopathological diagnosis of both tumours revealed an atypical meningioma of the brain and a uterine leiomyosarcoma. The patient underwent laparatomy and received six cycles of adjuvant chemotherapy.
We are the first to report a case of a woman with two separate primary neoplasms both diagnosed during pregnancy. Treatment options seem to be reduced in pregnant women and mainly depend on the patient's condition as well as the gestational age at presentation.
孕期子宫平滑肌肉瘤极为罕见。孕期脑膜瘤的发病率与同年龄组非孕期女性相当。我们报告一例在孕期同时诊断出原发性子宫平滑肌肉瘤和脑部非典型脑膜瘤的病例。
患者在妊娠31周时因全身性癫痫发作入院。检测到一个肿瘤性肿块并开始了初步保守治疗。患者在妊娠34周时通过剖宫产分娩婴儿。剖宫产期间切除了一个带蒂子宫肌瘤,并对脑部肿瘤进行了全切除。两种肿瘤的组织病理学诊断显示为脑部非典型脑膜瘤和子宫平滑肌肉瘤。患者接受了剖腹手术并接受了六个周期的辅助化疗。
我们是首例报告一名女性在孕期同时诊断出两种独立原发性肿瘤的病例。孕妇的治疗选择似乎有限,主要取决于患者的病情以及就诊时的孕周。