• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mega-dose vitamin C as therapy for human cancer?
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):E95; author reply E96. doi: 10.1073/pnas.0809328105. Epub 2008 Nov 24.
2
WITHDRAWN: Vitamin C supplementation for asthma.撤回：补充维生素C治疗哮喘。
Cochrane Database Syst Rev. 2013 Oct 23;2013(10):CD000993. doi: 10.1002/14651858.CD000993.pub4.
3
Vitamin C hypertension.维生素C与高血压
Am J Ther. 2003 May-Jun;10(3):234-5; author reply 235. doi: 10.1097/00045391-200305000-00014.
4
Vitamin C and vitamin E in pregnant women at risk of pre-eclampsia.先兆子痫风险孕妇中的维生素C和维生素E
Lancet. 2006 Jul 15;368(9531):198; author reply 199-200. doi: 10.1016/S0140-6736(06)69029-6.
5
Vitamin C and vitamin E in pregnant women at risk of pre-eclampsia.
Lancet. 2006 Jul 15;368(9531):198; author reply 199-200. doi: 10.1016/S0140-6736(06)69030-2.
6
Effect of the supplemental use of antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cancer.补充使用抗氧化剂维生素C、维生素E和辅酶Q10对癌症预防和治疗的作用。
Evid Rep Technol Assess (Summ). 2003 Oct(75):1-3.
7
[Vitamin C in complementary oncology--update 2009].[补充肿瘤学中的维生素C——2009年更新]
Med Monatsschr Pharm. 2009 Jul;32(7):263-7.
8
Cancer treatment and vitamin C: the debate lingers.癌症治疗与维生素C：争论仍在继续。
J Natl Cancer Inst. 1999 Dec 15;91(24):2073-5. doi: 10.1093/jnci/91.24.2073.
9
Antioxidants may retard cataract formation.抗氧化剂可能延缓白内障的形成。
Ann Pharmacother. 1994 Sep;28(9):1040-2.
10
Vitamin C as a cancer treatment: state of the science and recommendations for research.维生素C作为一种癌症治疗方法：科学现状与研究建议
Altern Ther Health Med. 2003 May-Jun;9(3):94-101.

引用本文的文献

1
New Insights into Aspirin's Anticancer Activity: The Predominant Role of Its Iron-Chelating Antioxidant Metabolites.阿司匹林抗癌活性的新见解：其铁螯合抗氧化代谢产物的主要作用
Antioxidants (Basel). 2024 Dec 29;14(1):29. doi: 10.3390/antiox14010029.
2
Structural Insight into the Catalytic Mechanisms of an L-Sorbosone Dehydrogenase.L-山梨糖脱氢酶催化机制的结构洞察。
Adv Sci (Weinh). 2023 Oct;10(30):e2301955. doi: 10.1002/advs.202301955. Epub 2023 Sep 7.
3
The Interplay of Ascorbic Acid with Quinones-Chelators-Influence on Lipid Peroxidation: Insight into Anticancer Activity.抗坏血酸与醌类螯合剂的相互作用——对脂质过氧化的影响：对抗癌活性的深入了解
Antioxidants (Basel). 2022 Feb 13;11(2):376. doi: 10.3390/antiox11020376.
4
Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine.具有必需过渡金属的螯合物配合物的作用机制研究：抗氧化/促氧化活性及其在医学中的应用。
Int J Mol Sci. 2022 Jan 23;23(3):1247. doi: 10.3390/ijms23031247.
5
Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications.试图解开抗坏血酸与铁相互作用之谜：氧化还原、螯合作用及治疗意义
Medicines (Basel). 2020 Jul 30;7(8):45. doi: 10.3390/medicines7080045.
6
Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone.维生素 C 和铁的氧化还原相互作用：去铁酮抑制其促氧化剂活性。
Int J Mol Sci. 2020 May 31;21(11):3967. doi: 10.3390/ijms21113967.
7
Vitamins and prostate cancer risk.维生素与前列腺癌风险。
Molecules. 2010 Mar 12;15(3):1762-83. doi: 10.3390/molecules15031762.

本文引用的文献

1
Vitamin C and cancer revisited.再探维生素C与癌症
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11037-8. doi: 10.1073/pnas.0806433105. Epub 2008 Aug 5.
2
Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.药理学剂量的抗坏血酸盐可作为一种促氧化剂，并减少小鼠体内侵袭性肿瘤异种移植物的生长。
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.
3
Phase I clinical trial of i.v. ascorbic acid in advanced malignancy.静脉注射维生素C用于晚期恶性肿瘤的I期临床试验。
Ann Oncol. 2008 Nov;19(11):1969-74. doi: 10.1093/annonc/mdn377. Epub 2008 Jun 9.
4
Modeling therapy resistance in genetically engineered mouse cancer models.在基因工程小鼠癌症模型中模拟治疗抗性
Drug Resist Updat. 2008 Feb-Apr;11(1-2):51-60. doi: 10.1016/j.drup.2007.11.002. Epub 2007 Dec 31.
5
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.抗坏血酸盐/甲萘醌联合诱导的氧化应激可杀死K562人慢性粒细胞白血病细胞，并抑制其在裸鼠体内的肿瘤生长。
Biochem Pharmacol. 2006 Sep 14;72(6):671-80. doi: 10.1016/j.bcp.2006.05.025. Epub 2006 Jul 7.
6
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via c-Jun NH2-terminal kinase-mediated phosphorylation at serine 15 in vitro and in vivo.白花丹素（5-羟基-2-甲基-1,4-萘醌）在体外和体内通过c-Jun氨基末端激酶介导的丝氨酸15位点磷酸化使p53积累，从而诱导A549细胞凋亡和细胞周期停滞。
J Pharmacol Exp Ther. 2006 Aug;318(2):484-94. doi: 10.1124/jpet.105.098863. Epub 2006 Apr 21.
7
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.白花丹醌（5-羟基-2-甲基-1,4-萘醌）通过调节p65和IκBα激酶的激活来抑制核因子κB（NF-κB）的激活及NF-κB调节的基因产物，从而增强细胞因子和化疗药物诱导的细胞凋亡。
J Biol Chem. 2006 Jun 23;281(25):17023-17033. doi: 10.1074/jbc.M601595200. Epub 2006 Apr 19.
8
High-dose vitamin C therapy: renewed hope or false promise?高剂量维生素C疗法：新希望还是虚假承诺？
CMAJ. 2006 Mar 28;174(7):956-7. doi: 10.1503/cmaj.060228.
9
Intravenously administered vitamin C as cancer therapy: three cases.静脉注射维生素C作为癌症治疗方法：三例病例
CMAJ. 2006 Mar 28;174(7):937-42. doi: 10.1503/cmaj.050346.
10
Ascorbate potentiates the cytotoxicity of menadione leading to an oxidative stress that kills cancer cells by a non-apoptotic caspase-3 independent form of cell death.抗坏血酸盐增强甲萘醌的细胞毒性，导致氧化应激，通过一种非凋亡的、不依赖半胱天冬酶-3的细胞死亡形式杀死癌细胞。
Apoptosis. 2004 Mar;9(2):223-33. doi: 10.1023/B:APPT.0000018804.26026.1a.

Mega-dose vitamin C as therapy for human cancer?

作者信息

Borst Piet

出版信息

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):E95; author reply E96. doi: 10.1073/pnas.0809328105. Epub 2008 Nov 24.

DOI:10.1073/pnas.0809328105
PMID:19033231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2596258/
Abstract
摘要