Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Molecules. 2010 Mar 12;15(3):1762-83. doi: 10.3390/molecules15031762.
Prostate cancer (PC) is the second most common cancer in men worldwide. Its prevention and treatment remain a challenge to clinicians. Here we review the relationship of vitamins to PC risk. Many vitamins and related chemicals, including vitamin A, retinoids, several B vitamins, vitamin C, vitamin D and vitamin E have shown their anti-cancer activities as anti-oxidants, activators of transcription factors or factors influencing epigenetic events. Although laboratory tests including the use of animal models showed these vitamins may have anti-PC properties, whether they can effectively prevent the development and/or progression of PC in humans remains to be intensively studied subjects. This review will provide up-to-date information regarding the recent outcomes of laboratory, epidemiology and/or clinical trials on the effects of vitamins on PC prevention and/or treatment.
前列腺癌（PC）是全球男性第二大常见癌症。其预防和治疗仍然是临床医生面临的挑战。在这里，我们回顾了维生素与 PC 风险的关系。许多维生素和相关化学物质，包括维生素 A、类视黄醇、几种 B 族维生素、维生素 C、维生素 D 和维生素 E，已显示出其作为抗氧化剂、转录因子激活剂或影响表观遗传事件的因素的抗癌活性。尽管包括使用动物模型在内的实验室测试表明这些维生素可能具有抗 PC 特性，但它们是否能有效预防 PC 的发生和/或进展，仍有待深入研究。本综述将提供有关实验室、流行病学和/或临床试验中维生素对 PC 预防和/或治疗影响的最新信息。
